Publications by authors named "Aysun Aksoy"

Background/aim: Syndesmophyte formation appears to be site-specific in ankylosing spondylitis (AS) and new bone formation seems to occur in regions of microtrauma that are prone to tensile forces. Pelvic and spinal parameters are unique for each individual. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance.

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Objectives: Pulmonary arterial involvement (PAI) is one of the most common causes of mortality in Behçet's disease (BD). In this study, we aimed to evaluate the clinical features, course, and recurrence risk factors of BD-associated PAI.

Methods: BD patients who were followed up in Marmara University BD outpatient clinic between 1990 and 2023 were included.

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Radiographic progression in Ankylosing spondylitis (AS) is driven by mechanical strain. A well-balanced spine provides a favorable weight distribution across the entheses. Pelvic parameters are useful in assessing the shape of the spine.

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Post-thrombotic syndrome (PTS) is a frequent and important consequence of deep vein thrombosis (DVT) for Behcet`s disease (BD) patients. Although various clinical scales are used to diagnose PTS, Villalta scale was accepted as the standard tool to diagnose and grade the severity of PTS. Poor quality of life (Qol) in the general population was defined for patients with PTS, however, studies in BD patients with PTS is limited.

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Introduction: Behcet's disease (BD) is a chronic inflammatory disorder with arterial vasculitis. Although, pulmonary artery aneurysm (PAA) is accepted as the prototypic arterial disorder, an increasing presence of pulmonary artery thrombosis (PAT) with or without aneurysms was also reported in recent studies. In this study, we aimed to describe computed tomography pulmonary angiography (CTPA) findings of pulmonary involvement and its correlation with symptoms and acute phase response in BD.

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Article Synopsis
  • The study used the CART algorithm to analyze treatment protocols and factors affecting oral ulcers in Behçet's syndrome patients across multiple countries.
  • Among 979 patients, findings revealed that those with irregular tooth brushing habits showed a higher usage of immunosuppressive (IS) medications, especially in males with major organ involvement.
  • The study emphasizes the importance of promoting better oral hygiene as part of treatment strategies for patients with Behçet's syndrome.
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Background: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment.

Methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis.

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Objectives: To analyse the clinical and laboratory factors associated with bamboo spine.

Methods: Data of patients fulfilling the 2009 ASAS classification criteria for axial spondyloarthritis, registered in the national, multicentre, longitudinal, and observational database of TReasure was analysed. Radiographs were assessed using the Bath Ankylosing Spondylitis Radiologic Index (BASRI).

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Objectives: Vascular Behçet's disease (VBD) is a systemic vasculitis involving both arterial and venous vessels of all sizes and occurring in up to 40% of patients with BD. VBD is the main cause of mortality in BD. Although commonly seen around the Mediterranean region, comparative studies in VBD are lacking.

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Objective: To evaluate key factors for presenteeism and activity impairment in multinational patients with Behçet's syndrome (BS) and recurrent aphthous stomatitis (RAS).

Methods: In this cross-sectional study, 364 BS patients from Jordan, Brazil, the United Kingdom and Turkey and 143 RAS patients from the United Kingdom and Turkey were included. The Work Productivity Activity Impairment (WPAI) scale was used for presenteeism and activity impairment.

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Article Synopsis
  • Deep vein thrombosis (DVT) is common in Behçet disease (BD) and often leads to post-thrombotic syndrome (PTS), which can be disabling; this study observed these relationships using Doppler ultrasound.
  • Among 205 patients with BD and DVT, 62% developed PTS, with significant differences in reflux and thrombosis scores compared to those without PTS; treatment with immunosuppressive therapy was linked to lower severe PTS rates.
  • Overall, the study indicates that using immunosuppressive treatment reduces severe PTS risk, while anticoagulation therapy can improve collateral blood flow, suggesting that Doppler ultrasound may be a helpful tool for predicting PTS in these patients.
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The aim of the present study was to examine the effects of age on mucocutaneous activity by using moderation analysis in Behçet's syndrome (BS). In this cross-sectional study, 887 BS patients (female : male, 481:406; mean age, 38.4 ± 10.

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Objectives: Vascular involvement is one of the major causes of morbidity and mortality in Behçet's disease (BD) patients. Immunosuppressive (IS) agents are the mainstay of vascular BD (VBD) treatment; however, up to one-third of patients relapse under conventional ISs. In this case series, we present the results of tumor necrosis factor-alpha (TNFα) inhibitor use for the treatment of VBD patients who were refractory to conventional ISs and corticosteroids.

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Objective: The aim of this multi-center study was to assess predictive factors for work-day loss as an indirect cost element in Behçet's syndrome (BS).

Methods: In this cross-sectional, multi-center study, 834 BS patients (F/M: 441/393, age mean: 38.4 ± 10.

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Article Synopsis
  • - The study aimed to assess patients' needs and measure oral ulcer activity in Behçet's syndrome (BS) using the Composite Index (CI) across 12 centers with 834 participants.
  • - Results showed that 65.1% of patients had oral ulcers, with activity being higher in those receiving non-immunosuppressive treatments for mild disease, while immunosuppressive treatments were more effective in severe cases.
  • - The findings indicated that oral ulcer activity is influenced by treatment type, disease severity, and duration, suggesting that the CI could be useful for evaluating treatment effectiveness in managing oral ulcers in BS.
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Objective: The aim of this study was to assess the contributing factors for oral ulcer activity in Behçet's disease (BD).

Methods: Ninety-two patients with BD (F/M: 42/50, mean age: 38.7±10.

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Article Synopsis
  • - The study aimed to investigate how oral health affects the severity of Behçet's disease (BD) by analyzing the dental and periodontal health of 194 patients over time.
  • - Results showed that worse oral health, indicated by the need for tooth extractions and presence of dental caries, correlated with a more severe disease course, especially in male patients.
  • - The findings suggest that improving oral health may help reduce disease severity in BD patients by addressing microbial factors that contribute to the condition.
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Background/aim: The TReasure registry, created in 2017, is an observational multicenter cohort that includes inflammatory arthritis patients. This article reviews the methodology and objectives of the TReasure registry established to collect data from rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients.

Methodology: Fifteen rheumatology centers in Turkey will contribute data to the TReasure database.

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Background/aims: The aim of this study is to investigate the utility of clinical [age, gender, mean arterial pressure (MAP)] and laboratory parameters [eGFR, hemoglobin (Hgb), serum levels of creatinine, uric acid, albumin, proteinuria, hematuria] and also histopathological lesions (Oxford classification parameters, crescents, intensity and pattern of staining for C3, C1Q, IgA, IgG, IgM) as progression markers in patients with IgA Nephropathy (IgAN).

Methods: A total of 111 IgAN patients with a follow-up period >1 year or who reached kidney failure [GFR category G5 chronic kidney disease (CKD)] <1 year were investigated. Primary endpoint was the development of kidney failure or eGFR decline ≥50% from the baseline.

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