2-Propyl-3-Aminoquinazoline-4(3H)-one Derivatives as Potential Androgen Receptor Inhibitors: Synthesis and Cytotoxicity Against PC3 Cell Line via In Vitro and In Silico Studies.

Twenty-one novel quinazolin-4(3H)-one derivatives were synthesized and evaluated for their cytotoxic effects against the PC3 prostate cancer cell line. Structural characterization was performed using FTIR, NMR, and HRMS spectroscopy. Cytotoxicity assays revealed that compound 1 exhibited the highest potency (IC = 4.

Safranin T- SDS- GO ternary system: A fluorescent pH sensor.

Graphene oxide (GO), one of the popular materials in recent years, has been synthesized according to the modified Hummers' method. Stable dispersions of different amounts of negatively charged GO were prepared in aqueous media. The GO/dye composites were prepared in deionized water by a simple method with the positively charged Safranin T compound (SfT), which is known to have strong fluorescence properties.