Publications by authors named "Aya G Elmarsafawi"
The combined effects of aging and cancer on immune cells were investigated in young versus aged mice harboring B cell lymphoma, and in T cells from young and aged B cell lymphoma patients. These analyses revealed that lymphoma alone is sufficient to trigger transcriptional, epigenetic, and phenotypic alterations in young T cells that manifest in aged T cells. In contrast, aged T cells are largely resistant to lymphoma-induced changes.
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- Glutaminolysis is essential for T cell activation and metabolic changes, with glutamine serving as a key carbon source for producing polyamines—putrescine, spermidine, and spermine.
- These polyamines are crucial for T cell proliferation and the production of hypusine, which is important for protein synthesis in T cells.
- Inhibiting the glutamine/polyamine/hypusine pathway enhances memory T cell development and boosts the immune response in both human CD8+ T cells and CAR-T cells, suggesting potential therapeutic strategies.
TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate.
Cancer Immunol Res
October 2022
Chronic T-cell receptor (TCR) signaling in the tumor microenvironment is known to promote T-cell dysfunction. However, we reasoned that poorly immunogenic tumors may also compromise T cells by impairing their metabolism. To address this, we assessed temporal changes in T-cell metabolism, fate, and function in models of B-cell lymphoma driven by Myc, a promoter of energetics and repressor of immunogenicity.
View Article and Find Full Text PDFObjectives: Comparing different perioperative statin regimens for the prevention of post-coronary artery bypass grafting adverse events.
Design: A randomized, prospective study.
Setting: Cardiothoracic surgical units in a government hospital.