Publications by authors named "Avinash Chintala"
Faraday Discuss
September 2024
Article Synopsis
- mRNA therapies have become popular, especially after the approval of mRNA vaccines against SARS-CoV-2, but large-scale production faces significant challenges.
- The production process can be inefficient and costly due to issues with incorporating necessary cap analogs and the creation of unwanted double-stranded RNA byproducts that can trigger immune reactions.
- Researchers have developed a new RNA polymerase called T7-68 that improves the incorporation of cap analogs and reduces the presence of harmful dsRNA, enhancing the efficiency of mRNA production.
