Publications by authors named "Audrey D Labbe"
Article Synopsis
- Direct-acting antivirals are essential to fight COVID-19 by targeting the papain-like protease (PLpro) of SARS-CoV-2, which is crucial for viral replication and undermines the host immune response.* -
- Researchers developed a series of covalent inhibitors of PLpro, enhancing a noncovalent inhibitor, resulting in a compound that shows strong inhibitory activity and specificity against SARS-CoV-2 variants without affecting human deubiquitinases.* -
- An X-ray co-crystal structure confirmed the binding of the compound to PLpro, supporting its design and illustrating the potential for further development of these inhibitors for therapeutic use.*
Drought stress negatively impacts microbial activity, but the magnitude of stress responses is likely dependent on a diversity of belowground interactions. individuals and no-plant bulk soils were exposed to extended drought (∼0.03% gravimetric water content [GWC] after 12 days), rewet, and a 12-day "recovery" period to determine the effects of plant presence in mediating soil microbiome stability to water stress.
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