Photoinduced Charge Transfer between Metal Halide Perovskite and Ru-Polypyridyl Complexes Toward Biocatalytic Reactions.

Vacancy-ordered Bi-based perovskites, such as CsBiBr (CBB), exhibit relatively high Lewis acidity due to Bi⁺ centers, providing favorable acidic sites for organic transformations. Coupled with their tuneable optoelectronic properties, these features render CBB an efficient photocatalyst for various acid-catalyzed reactions. In this study, CBB is conjugated with a classical Ru(II)-polypyridyl photosensitizer (RuPS) to form a hybrid material, CBB/RuPS, capable of facilitating thermodynamically favourable inner-sphere electron transfer.

Microtubule-Targeting NAP Peptide-Ru(II)-polypyridyl Conjugate As a Bimodal Therapeutic Agent for Triple Negative Breast Carcinoma.

Triple-negative breast cancer (TNBC) poses significant treatment challenges due to its high metastasis, heterogeneity, and poor biomarker expression. The N-terminus of an octapeptide NAPVSIPQ () was covalently coupled to a carboxylic acid derivative of Ru(2,2'-bipy) () to synthesize an N-stapled short peptide-Rubpy conjugate (). This photosensitizer (PS) was utilized to treat TNBC through microtubule (MT) targeted chemotherapy and photodynamic therapy (PDT).

Multimodal Biofilm Inactivation Using a Photocatalytic Bismuth Perovskite-TiO-Ru(II)polypyridyl-Based Multisite Heterojunction.

Infectious bacterial biofilms are recalcitrant to most antibiotics compared to their planktonic version, and the lack of appropriate therapeutic strategies for mitigating them poses a serious threat to clinical treatment. A ternary heterojunction material derived from a Bi-based perovskite-TiO hybrid and a [Ru(2,2'-bpy)(4,4'-dicarboxy-2,2'-bpy)] (2,2'-bpy, 2,2'-bipyridyl) as a photosensitizer (RuPS) is developed. This hybrid material is found to be capable of generating reactive oxygen species (ROS)/reactive nitrogen species (RNS) upon solar light irradiation.