Assessing Readability, Understandability, and Actionability of ACPA Educational Resources and Utility of LLMs to Improve Accessibility for Caregivers.

ObjectiveIt is important for parents and caregivers of children with cleft lip and/or palate to easily understand educational resources provided by the American Cleft Palate-Craniofacial Association (ACPA). This study aimed to assess the readability, understandability, and actionability of ACPA resources, and the utility of large language models (LLMs) in their improvement.DesignACPA resources were collected and assessed using a readability calculator and 2 readers assessed using the Patient Educational Material Assessment Tool (PEMAT).

Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro.

Human airways contain specialized rare epithelial cells including CFTR-rich ionocytes that regulate airway surface physiology and chemosensory tuft cells that produce asthma-associated inflammatory mediators. Here, using a lung cell atlas of 311,748 single cell RNA-Seq profiles, we identify 687 ionocytes (0.45%).

Risk Factors for Obstructive Sleep Apnea in Patients With Cleft Palate.

Background: Obstructive sleep apnea (OSA) involves repeated episodes of upper airway obstruction during sleep. Patients with cleft palate (CP) are at higher risk for OSA due to craniofacial anatomical differences. We aimed to characterize the prevalence of OSA and identify risk factors for OSA in patients with CP.

Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma.

Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving the understanding of the tumor microenvironment (TME). Here, we utilized high-throughput, single-cell RNA sequencing (scRNA-seq) to de novo identify 54 expression programs and construct a comprehensive cellular catalog of the PM TME. We found four cancer-intrinsic programs associated with poor disease outcome and a novel fetal-like, endothelial cell population that likely responds to VEGF signaling and promotes angiogenesis.

Complications Following Tissue Expander-Based Reconstruction in Pediatric Burn Injuries: A Retrospective Analysis.

Background: Tissue expansion has been widely used to reconstruct soft tissue defects following burn injuries in pediatric patients, allowing for satisfactory cosmetic and functional outcomes. Factors impacting the success of tissue expander (TE)-based reconstruction in these patients are poorly understood. Herein, we aim to determine the risk factors for postoperative complications following TE-based reconstruction in pediatric burn patients.

Changes in opioid treatment programs and harm reduction provider services during the COVID-19 pandemic: Findings from 10 states.

Harm reduction and opioid treatment programs (OTPs) modified service delivery based on rapid changes to state and federal regulations during the COVID-19 pandemic. There is little evidence on how these regulations changed the delivery of medication for opioid use disorder and harm reduction services and whether certain regulations should be made permanent. This study explores how harm reduction OTPs across the United States leveraged changes in regulations and responded to impacts of COVID-19 to continue providing services and perspectives on future legislation that regulates their practice and practice sites.