Publications by authors named "Asif Qayoom"
Aim Of The Study: The study was performed to understand the detailed mechanism of diabetic wound healing by bilirubin-deferoxamine (DFO) combination on topical application.
Materials And Methods: There were two study groups, control, and treatment. The granulation tissues collected on different days (3, 7, 14, and 19) were studied in detail for inflammatory mediators, angiogenesis markers, epithelialization, and oxidative stress parameters.
Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats.
Eur J Pharmacol
September 2019
Article Synopsis
- Nanoparticles have a higher chance of entering cells due to their larger surface area-to-volume ratio, making them more effective in modulating molecular events in tissues.
- A study showed that deferoxamine enhances wound healing in diabetic rats, and its nanoparticle form significantly improved healing rates and biological responses compared to regular deferoxamine.
- In particular, the most effective treatment group (Group V) showed greater collagen deposition and neovascularization, leading to faster closure of wounds and lower inflammation indicators, suggesting the potential for this formulation in diabetic wound therapy.