Graphene oxide functionalized with chitosan based nanoparticles as a carrier of siRNA in regulating Bcl-2 expression on Saos-2 & MG-63 cancer cells and its inflammatory response on bone marrow derived cells from mice.

Presently, quite a lot of research that are being carried out to find a potential cure for cancer and many had made to clinical trial stage as well. In the present study, we focus on use of a novel graphene oxide functionalized chitosan nanoparticle targeting Saos-2 and MG-63 osteosarcoma cells. The graphene oxide chitosan nanoparticles were loaded with siRNA, studied for in vitro release with varying concentration & pH, and fitted to peppas model.

The effect of chlorotrimethylsilane on bonding of nano hydroxyapatite with a chitosan-polyacrylamide matrix.

Stimuli sensitive biodegradable polymers have important applications in the fields of drug delivery and tissue engineering. In this study, biodegradable composite films of chitosan-polyacrylamide-nano hydroxyapatite (Cs-PAAm-nHA) with different concentrations of Chlorotrimethylsilane (CTMS) were fabricated and characterized using Fourier transform infrared (FTIR) spectroscopy. FTIR and XRD results suggested that CTMS functioned to couple nHA with the Cs-PAAm polymer matrix.