Publications by authors named "Apolline Urman"
A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases.
J Am Soc Nephrol
February 2025
Key Points: MQ232, a disulfide-bond reticulated peptide derived from a natural snake toxin, was optimized as a new aquaretic drug candidate. MQ232 showed very low acute and chronic toxicity in rat and a biodistribution in mice strongly in favor of the kidney organs. MQ232 induced a sole aquaretic effect and demonstrated high activities on hyponatremia and polycystic kidney disease models.
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- Brevetoxins (BTXs) are toxic compounds primarily linked to neurotoxic shellfish poisoning (NSP) in humans, prompting studies to assess their effects.
- An acute oral toxicity study was conducted in mice to evaluate the impact of various doses of BTX-3, revealing sex-based differences in sensitivity and symptoms.
- Key findings showed that BTX-3 caused rapid and temporary decreases in body weight, temperature, and muscle activity, with more severe effects observed in males, particularly at higher doses.