Unveiling the response of efflux pump genes to delamanid in Mycobacterium tuberculosis H37Rv: a transcriptomic analysis.

Overexpression of efflux pumps has been associated with drug resistance in Mycobacterium tuberculosis. However, their specific role in delamanid resistance remains unclear. This study aimed to identify efflux pump genes influenced by delamanid exposure through transcriptomic analysis.

Pioneering nucleation for stable ultraviolet-to-deep-blue illuminating two-dimensional perovskite nanoplates by using saturated salt solution.

Two-dimensional (2D) metal halide perovskites are promising materials for efficient ultraviolet-to-blue light emission. However, synthesizing stable, phase-pure, and highly fluorescent 2D perovskite nanomaterials remains challenging. Here, a unique nucleation strategy is used for stabilizing the nucleation of the 2D phase in perovskite stock solution, increasing the luminance and stability of the resulting nanoplates.

Draft genome sequence of isolated from the sputum sample of a patient with pulmonary tuberculosis.

We report the draft genome of , a rapidly growing nontuberculous mycobacterium, isolated from the sputum sample of a patient undergoing treatment for multidrug-resistant tuberculosis in Delhi, India. The 6,366,717-bp genome contains 6,124 coding sequences, one 5S rRNA, three 16S rRNAs, six 23S rRNAs, and 49 tRNAs.

Discovery of a Thermodynamic-Control Two-Dimensional CsPbI Perovskite with a Unique Green Emission Color via Dynamic Structural Transformation.

New perovskite materials of two-dimensional (2D) all-inorganic Ruddlesden-Popper (RP) perovskite CsPbI nanosheets were successfully obtained from the structural transformation of 2D PR-phase CsPbI nanosheets. The 2D RP-phase CsPbI perovskite nanosheets exhibited unique green emission with an emission wavelength of ∼500 nm. The crystal structure of the 2D RP-phase CsPbI perovskite nanosheets was determined by powder X-ray diffraction (XRD), high-resolution transmission electron microscopy, and atomic force microscopy.

Stress combinations and their interactions in plants database: a one-stop resource on combined stress responses in plants.

We have developed a compendium and interactive platform, named Stress Combinations and their Interactions in Plants Database (SCIPDb; http://www.nipgr.ac.

Expression of mammalian cell entry genes in clinical isolates of M. tuberculosis and the cell entry potential and immunological reactivity of the Rv0590A protein.

Mammalian cell entry (mce) operons play a vital role in cell invasion and survival of M. tuberculosis. Of the mce genes, the function of Rv0590A is still unknown.

Identification and analysis of proline-glutamate/proline-proline-glutamate proteins of complex: A comparison of computational web-based tools.

Background: Understanding the protein's subcellular localization and secretory nature can greatly improve the target identification for diagnostic assays and drug discovery, although their identification in laboratory experiments is a time-consuming and labor-intensive process. In order to identify proteins that could be targeted for therapeutic intervention or the development of diagnostic assays, we used a variety of computational tools to predict the subcellular localization or secretory nature of mycobacterial proline-glutamate/proline-proline-glutamate (PE/PPE) proteins.

Methods: PSORTb version 3.

Spectrophotometric Evaluation of Translucency of Various Commercially Available Zirconium Oxide Ceramic Systems: An Study.

Aim: To evaluate and compare the translucency of various commercially available zirconium oxide ceramic systems, i.e., Ceramill® Zolid Classic, Ceramill® Zi, and DD Bio ZX²71 by using a dual beam UV-visible spectrophotometer.

One-pot ultrasonicated synthesized lead-less hybrid perovskite nanocrystals: structural, morphological and optical analysis.

In contemporary years, hybrid lead halide perovskites nanocrystals (HPNCs) have emerged as core materials for low-cost solution-processable photovoltaic, light-emitting devices as well as in other optoelectronic fields, such as high-efficiency perovskite fluorescent quantum dots (quantum dot, QD). Although the high efficiency makes them an attractive active material, reducing the Pb-toxicity and enhancing the stability while sustaining the efficiency of the HPNCs devices is important for their successful commercialization in future. Here, we report for the first time the fabrication of excellent quality Pb-less, MAPbSnBr( = 0 to 0.

Sweetening Lithium Metal Interface by High Surface and Adhesive Energy Coating of Crystalline α-d-Glucose Film to Inhibit Dendrite Growth.

The notorious growth of lithium (Li) dendrites and the instability of the solid electrolyte interface (SEI) during cycling make Li metal anodes unsuitable for use in commercial Li-ion batteries. Herein, the use of simple sugar coating (α-d-glucose) is demonstrated on top of Li metal to halt the growth of Li dendrites and stabilize the SEI. The α-d-glucose layer possesses high surface and adhesive energies toward Li, which promote the homogenous stripping and plating of Li ions on top of the Li metal.

MTO1-RESPONDING DOWN 1 (MRD1) is a transcriptional target of OZF1 for promoting salicylic acid-mediated defense in Arabidopsis.

OZF1 promotes the transcription of MRD1, which is essential for SA-mediated defense against virulent and avirulent bacterial pathogens in Arabidopsis. Salicylic acid (SA) is critical for defense against biotrophic pathogens. A trans-activator protein NPR1 plays significant roles in SA-signaling.

Skin and soft-tissue infections due to rapidly growing mycobacteria: An overview.

Background: Rapidly growing mycobacteria (RGM) are increasingly being recognized as potential pathogens. RGM, particularly Mycobacterium abscessus, Mycobacterium fortuitum, and Mycobacterium chelonae, have been observed in both pulmonary and extrapulmonary infections including cutaneous, soft-tissue, and wound infections. However, there are limited reports of these potential pathogens from skin and soft-tissue infections.

μDrop: Multi-analyte portable electrochemical-sensing device for blood-based detection of cleaved tau and neuron filament light in traumatic brain injury patients.

Over 27 million individuals are affected every year worldwide with central nervous system (CNS) injuries. These injuries include but are not limited to traumatic brain injury (TBI) and spinal cord injury (SCI). CNS injuries remain a significant public health concern which demands reliable tools for rapid, on-sight, on-field, and point-of-care diagnostic (POC) solutions.

Draft Genome Sequence of Mycobacterium simiae, a Potential Pathogen Isolated from the Normal Human Oral Cavity.

We report the draft genome sequence of , a slowly growing nontuberculous mycobacterium (NTM) isolated from a mouthwash sample of a healthy person. This genome of 6,603,693 bp exhibited a 66.13% GC content and 6,391 genes with 6,257 coding sequences, 3 rRNAs, and 78 tRNAs.

The MPB64 immunochromatography assay: an analysis of doubtful results.

Culture remains the gold standard for tuberculosis (TB) diagnosis, and the mycobacteria growth indicator tube (MGIT), endorsed by the World Health Organization (WHO), is widely used. Further identification of a positive culture is done with the help of an immunochromatography assay, which often shows faint bands that are difficult to interpret. We analysed 125 BACTEC MGIT culture positive results, of which 11/16 (68.

Layered perovskite materials: key solutions for highly efficient and stable perovskite solar cells.

Metal halide perovskites having three-dimensional crystal structures are being applied successfully in various optoelectronic applications. To address their most challenging issues-instability and toxicity-without losing efficiency, lower-dimensional perovskites appear to be promising alternatives. Recently, two-dimensional (2D) perovskite solar cells have been developed exhibiting excellent photostability and moisture-stability, together with moderate device efficiency.

Modulating Performance and Stability of Inorganic Lead-Free Perovskite Solar Cells via Lewis-Pair Mediation.

Fully inorganic perovskites based on Bi and Sb are emerging as alternatives that overcome the toxicity and low stability of their Pb-based perovskite counterparts. Nevertheless, the thin film fabrication of Pb-free perovskites remains a struggle, with poor morphologies and incomplete conversions greatly inhibiting device performance. In this study, we modulated the crystallization of an all-inorganic dimer phase of a Sb perovskite (d-CsSbI) through gradual increase in the annealing temperature, accompanied by the use of Lewis bases for adduct formation.

An overview of pulmonary infections due to rapidly growing mycobacteria in South Asia and impressions from a subtropical region.

Background: Rapidly growing mycobacteria (RGM) comprise nearly half of the validated species of nontuberculous mycobacteria (NTM) and have been reported to have a higher incidence in Asia as compared to Europe and America. There is limited information on RGM infections from South Asia. Hence, the present study aimed to ascertain the incidence of pulmonary infections due to RGM in Delhi and to review the status of available information on the prevalence of RGM in South Asia, a region endemic for tuberculosis.

Core-Twisted Tetrachloroperylenediimides: Low-Cost and Efficient Non-Fullerene Organic Electron-Transporting Materials for Inverted Planar Perovskite Solar Cells.

Herein, core-twisted tetrachloroperylenediimides (ClPDIs) were introduced as new efficient electron-transporting materials (ETMs) to replace the commonly used fullerene acceptor PC BM in inverted planar perovskite solar cells (PSCs). ClPDI showed a low-lying lowest unoccupied molecular orbital (LUMO) energy level of -3.95 eV, which was compatible with the conduction band of CH NH PbI Cl (-3.

Lead-Free Antimony-Based Light-Emitting Diodes through the Vapor-Anion-Exchange Method.

Hybrid lead halide perovskites continue to attract interest for use in optoelectronic devices such as solar cells and light-emitting diodes. Although challenging, the replacement of toxic lead in these systems is an active field of research. Recently, the use of trivalent metal cations (Bi and Sb) that form defect perovskites ABX has received great attention for the development of solar cells, but their light-emissive properties have not previously been studied.

Soluble Graphene Nanosheets for the Sunlight-Induced Photodegradation of the Mixture of Dyes and its Environmental Assessment.

Currently, the air and water pollutions are presenting the most serious global concerns. Despite the well known tremendous efforts, it could be a promising sustainability if the black carbon (BC) soot can be utilized for the practical and sustainable applications. For this, the almost complete aqueous phase photodegradation of the three well-known organic pollutant dyes as crystal violet (CV); rhodamine B (RhB); methylene blue (MB) and their mixture (CV + RhB + MB), by using water-soluble graphene nanosheets (wsGNS) isolated from the BC soot under the influence of natural sunlight is described.

Optimization of culture conditions for mass production and bio-formulation of using response surface methodology.

Use of agro-waste for production of value added products is a good alternative for developing low-cost carriers for formulation of -based bio-products. It provides avenues for safe utilization of wastes, while reducing cost and environment pollution load of waste disposal. The present study was undertaken to find suitable agro-waste for economical and higher mass production of TvR1 under solid-state fermentation, optimizing culture conditions using mathematical model and assessing effect of formulated bio-product on growth of Spinach ().

AtOZF1 Positively Regulates Defense Against Bacterial Pathogens and NPR1-Independent Salicylic Acid Signaling.

Plant hormone salicylic acid (SA) plays critical roles in defense signaling against biotrophic pathogens. Pathogen inoculation leads to SA accumulation in plants. SA activates a transactivator protein NPR1, which, in turn, transcriptionally activates many defense response genes.