Publications by authors named "Antoine Collomb-Clerc"
Objective: The objective of this study was to investigate the relationships among subthalamic nucleus (STN) activity, gait initiation (GI), and freezing of gait (FOG) in patients with Parkinson's disease (PD).
Methods: We recorded GI and STN local field potentials (LFPs) via externalized cables in 38 patients with PD (35 reporting FOG in daily life), both OFF- and ON-dopamine (DOPA). GI was also recorded in 24 age-matched controls.
Article Synopsis
- Neural activity in the ventromedial prefrontal cortex (vmPFC) and anterior insula (aIns) is linked to economic decision-making and confidence, but their causal relationships were previously unclear.
- By using intracranial electrical stimulation data from epilepsy patients engaged in an economic choice task, researchers found that stimulation effects on decision-making varied based on the specific brain region targeted along a dorso-ventral axis.
- Stimulation of the ventral aIns decreased risk-taking by heightening sensitivity to losses, while stimulation in the dorsal aIns and ventral vmPFC increased risk-taking by diminishing loss sensitivity; additionally, aIns stimulation lowered participants' confidence regardless of the precise area stimulated.
Reinforcement-based adaptive decision-making is believed to recruit fronto-striatal circuits. A critical node of the fronto-striatal circuit is the thalamus. However, direct evidence of its involvement in human reinforcement learning is lacking.
View Article and Find Full Text PDFFreezing of gait depends on cortico-subthalamic network recruitment following STN-DBS in PD patients.
Parkinsonism Relat Disord
November 2022
Introduction: Subthalamic deep-brain-stimulation (STN-DBS) is an effective means to treat Parkinson's disease (PD) symptoms. Its benefit on gait disorders is variable, with freezing of gait (FOG) worsening in about 30% of cases. Here, we investigate the clinical and anatomical features that could explain post-operative FOG.
View Article and Find Full Text PDFBackground: Dopa-resistant freezing of gait (FOG) and falls represent the dominant motor disabilities in advanced Parkinson's disease (PD).
Objective: We investigate the effects of deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR), comprised of the pedunculopontine (PPN) and cuneiform (CuN) nuclei, for treating gait and balance disorders, in a randomized double-blind cross-over trial.
Methods: Six PD patients with dopa-resistant FOG and/or falls were operated for MLR-DBS.
Objective: Freezing of gait (FOG) represents a major burden for Parkinson's disease (PD) patients. High-frequency (130-Hz) subthalamic deep-brain-stimulation (STN-DBS) has been reported to aggravate FOG whereas lowering the frequency to 60-80 Hz improves FOG. To further understand the effects of STN-DBS on FOG, we assessed the effects of 80-Hz and 130-Hz STN-DBS on gait initiation performance, in relation to motor and executive function processing.
View Article and Find Full Text PDF