MreB Filaments in the Elongasome Modulate E. coli Membrane Curvature.

MreB, a bacterial actin homolog, plays a pivotal role in defining the shape of rod-shaped bacteria by coordinating peptidoglycan synthesis during cell elongation. It forms filaments that interact with the cytosolic leaflet of the cell membrane, as well as with membrane proteins and other cytosolic proteins. In this study, molecular dynamics (MD) simulations were used to investigate the interactions between Escherichia coli (E.