Enhanced Antibiofilm Activity of Copper Nanoparticles Stabilized With Polyvinyl Pyrrolidone and Polyvinyl Alcohol Against Pseudomonas aeruginosa and Staphylococcus aureus.

Pseudomonas aeruginosa and Staphylococcus aureus are biofilm-forming pathogens that contribute to persistent infections and exhibit high resistance to conventional antibiotics. In the present study, copper nanoparticles (Cu-NPs) were synthesized using polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) as polymeric stabilizing agents to evaluate their potential in biofilm inhibition. The synthesized Cu-NPs were characterized by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier-Transform Infrared (FT-IR) spectroscopy, Dynamic Light Scattering (DLS), zeta potential, Field Emission Scanning Electron Microscopy (FE-SEM), Energy-Dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD).

From Structure to Function: Isatin Derivatives as a Promising Class of Antiviral Agents.

A range of heterocyclic compounds, including Isatin (oneH-indole-2, 3-dione) and its by-products, have been shown to represent potential unit blocks in the synthesis of potential medicinal agents. Numerous studies have been carried out on isatin, its synthesis, biological uses, and its chemical composition since when it was discovered. Functionally, these isatin-containing heterocycles have demonstrated antibacterial, antidiabetic, antiviral, antitubercular, and anticancer properties, among many others.