Short-term incidence and risk of atrial fibrillation in patients with hypertrophic cardiomyopathy receiving cardiac myosin inhibitors: A systematic review and meta-analysis.

Background And Aims: Atrial fibrillation (AF) is the most common arrhythmia in hypertrophic cardiomyopathy (HCM) and is associated with increased morbidity and mortality. Cardiac myosin inhibitors (CMIs) are novel therapies for obstructive HCM. Recent studies suggested possible increased AF incidence with CMI use despite amelioration of left atrial dysfunction; but data are conflicting across studies.

Ideal Navitor Implant Depth for Redo-TAVR Feasibility and Coronary Access: A CT Simulation Study.

Background: The impact of implant depth of the Abbott Navitor intra-annular, self-expanding valve on redo-transcatheter aortic valve replacement (TAVR) feasibility is unknown.

Objectives: The authors sought to determine the feasibility of redo-TAVR and coronary access with Edwards Sapien 3 (S3) valve after initial Navitor valve, based on various implant depths on computed tomography (CT) simulation.

Methods: Using 2050 pre-TAVR CTs of patients with native aortic stenosis, initial Navitor TAVR simulations were done at 3 implant depths (0 mm, 3 mm, and 5 mm), with frame expansion assumed at native annular dimensions and commissural alignment not achievable.

Utility of the Euroscore II in Predicting Long-Term Outcomes in a Contemporary Australian Cohort With Complex Coronary Artery Disease.

The EuroSCORE II is a widely used risk stratification tool for estimating perioperative mortality in cardiac surgery. However, its prognostic utility in broader coronary artery disease (CAD) management, including in patients undergoing percutaneous coronary intervention (PCI) or medical therapy, is less well defined. We conducted a retrospective cohort study of patients with complex CAD discussed in a multidisciplinary Heart Team meeting at a tertiary Australian centre (2019-2024).

Ultra-massive fluid transfusion in adult liver transplant recipients: A single center observational study.

Introduction: Patients undergoing liver transplantation may require large volumes of fluid to maintain hemodynamic stability and treat coagulopathy. This study aimed to determine the prevalence of ultra-massive fluid transfusion and to examine its association with clinical outcomes. We defined an ultra-massive fluid transfusion a priori as a transfusion volume of >20 liters of crystalloids, colloids, blood and blood products administered intraoperatively and within the first 24 hours postoperatively.

Cannabis use and atrial arrhythmias: A systematic review and meta-analysis of large populational studies.

Background: Delta-9-tetrahydrocannabinol, a major component of cannabis, causes sympathetic stimulation and endothelial dysfunction. A recent American Heart Association consensus document has outlined cardiovascular risks associated with cannabis use. However, there are limited data surrounding atrial arrhythmias (AA).

Abdominal aortic calcification on routine preoperative computed tomography-A novel cardiovascular risk prediction tool in liver transplant patients.

Cardiovascular (CV) disease is a leading cause of postoperative mortality following liver transplantation (LT). The presence of abdominal aortic calcification (AAC) has been linked to CV events in the general population. We sought to investigate whether AAC on routine pre-transplant CT can improve the prediction of coronary artery disease, post-LT major adverse cardiovascular events (MACEs) or long-term mortality.

Blunted cardiac reserve as a marker of cirrhotic cardiomyopathy-Cardiac outcomes following liver transplantation and comparison to the existing guidelines.

Cirrhotic cardiomyopathy (CCM) is an underrecognized risk factor for cardiac events in patients undergoing liver transplantation (LT). Blunted cardiac reserve (BCR) is an emerging indicator of CCM, although it has not been integrated into diagnostic guidelines. This study assesses posttransplant cardiac outcomes and mortality in patients with BCR compared with current CCM diagnostic guidelines, focusing on diastolic indices.

Management of asymptomatic severe aortic stenosis: A critical review of guidelines and clinical outcomes.

Background: Asymptomatic severe aortic stenosis (AS) poses a clinical challenge with variations in recommendations for management.

Objectives: We sought to compare contemporary guidelines focusing on asymptomatic AS management and present a summary of contemporary studies on early intervention in these patients.

Methods: Systematic search of electronic databases was conducted with guidelines analyzed using a comparative matrix.

Development of a Novel BifurcAID Risk Score to Predict MACE Following Coronary True Bifurcation Intervention.

Background: Percutaneous coronary intervention (PCI) for true bifurcation lesions is associated with a higher risk of adverse clinical events.

Objectives: This study sought to establish a point-based score using clinical and angiographic characteristics in true bifurcation lesions before PCI to predict the risk of major adverse cardiovascular events (MACE).

Methods: A total of 1,896 consecutive patients undergoing PCI for true bifurcation lesions between 2012 and 2019 in our institution were included.

Characteristics, outcomes, and complications among nonagenarian and centenarian patients admitted to the intensive care unit: a scoping review.

Introduction: Nonagenarians and centenarians are a growing and vulnerable groups of patients admitted to ICU. There is limited information on their characteristics, outcomes, and complications.

Methods: We performed a scoping review of studies focused on nonagenarians and centenarians admitted to ICU.

Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease.

Coarctation of the aorta (CoA) is one of the most common types of congenital heart disease. Unfortunately, there is a high prevalence of hypertension and late cardiovascular mortality in patients with CoA despite successful repair. The growing impact of acquired cardiovascular disease remains a significant concern as the adult congenital heart disease population continues to rapidly expand and age.

The Perioperative NonaGEnaRIan And cenTenarian suRgICal (GERIATRIC) Risk Stratification Tool.

Objective: To develop age-appropriate nonaGEnaRIan And cenTenarian suRgICal (GERIATRIC) risk tool for classifying patients who may or may not develop postoperative complications or die within their index hospital admission.

Background: There are no validated perioperative risk stratification tools for use in nonagenarian and centenarian patients-people aged 90 to 99 years and >100 years.

Methods: In this retrospective observational study, nonagenarians and centenarians undergoing any surgical procedure were profiled.

The impact of stress testing to guide PCI in patients with chronic coronary disease.

Background: Guidelines and international appropriate use criteria increasingly endorse non-invasive stress testing to evaluate patients with suspected chronic coronary disease (CCD). We sought to review the real-world utilisation of non-invasive stress testing and investigate whether their use prior to PCI associates with outcomes in patients with CCD.

Methods: Consecutive patients from a multicentre registry who underwent PCI for CCD between 2006 and 2018 were included.

Contrast-Induced Encephalopathy Following Transcatheter Aortic Valve Replacement: A Case Series.

Contrast-induced encephalopathy (CIE) is an idiopathic reaction following iodine-contrast dye administration in patients undergoing angiographic procedures. While it has been well-documented following coronary and carotid interventions, literature on CIE following transcatheter aortic valve replacement is limited. We report the multidisciplinary management of 3 patients with CIE following transcatheter aortic valve replacement.

Management of Acute Coronary Syndromes in Older People: Comprehensive Review and Multidisciplinary Practice-Based Recommendations.

Managing health care for older adults aged 75 years and older can pose unique challenges stemming from age-related physiological differences and comorbidities, along with elevated risk of delirium, frailty, disability, and polypharmacy. This review is aimed at providing a comprehensive analysis of the management of acute coronary syndromes (ACS) in older patients, a demographic substantially underrepresented in major clinical trials. Because older patients often exhibit atypical ACS symptoms, a nuanced diagnostic and risk stratification approach is necessary.

Mortality After Procedural or Spontaneous Myocardial Infarction.

Background: It remains unclear whether procedural myocardial infarction (pMI) and spontaneous myocardial infarction (spMI) have a similar impact on prognosis.

Objectives: The aim of this study was to assess mortality after pMI and spMI.

Methods: Patients with chronic coronary syndrome (CCS) and baseline troponin ≤1× the upper reference level (URL) or with acute spMI who underwent percutaneous coronary intervention (PCI) were included.

Methadone in combination with magnesium, ketamine, lidocaine, and dexmedetomidine improves postoperative outcomes after coronary artery bypass grafting: an observational multicentre study.

Background: An optimal pharmacological strategy for fast-track cardiac anesthesia (FTCA) is unclear. This study evaluated the effectiveness and safety of an FTCA program using methadone and non-opioid adjuvant infusions (magnesium, ketamine, lidocaine, and dexmedetomidine) in patients undergoing coronary artery bypass grafting.

Methods: This retrospective, multicenter observational study was conducted across private and public teaching sectors.