Can celiac serology alone be used as a marker of duodenal mucosal recovery in children with celiac disease on a gluten-free diet?

Objectives: Assessment of treatment response in children with celiac disease (CD) after commencing a strict gluten-free diet (GFD) is generally based on the resolution of clinical features and normalization of serology. Recent adult studies have shown that serologic markers do not correlate with mucosal recovery. We aimed (i) to determine whether anti-tissue transglutaminase immunoglobulin (Ig)A (tTG) and anti-deamidated gliadin peptide IgG (DGP) antibodies are sensitive and specific markers of mucosal recovery in children with CD on a GFD for at least 12 months, and (ii) to determine whether a validated dietary questionnaire of compliance can identify patients with mucosal recovery.

Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial.

Objective: We assessed the safety and tolerability of an olive oil-based lipid emulsion compared with a soybean-based lipid emulsion in critically ill neonates.

Methods: A double-blinded, randomized study was conducted in critically ill neonates requiring parenteral nutrition in the first week of life. Infants were randomized to receive a lipid emulsion based on olive oil (OO; ClinOleic) or soybean oil (SO; Intralipid) for a minimum of 5 d.

Acute gastroenteritis in children.

Background: Gastroenteritis (GE) is inflammation of the mucous membranes of the gastrointestinal tract, and is characterised by vomiting and/or diarrhoea. The most common causes are viruses, but bacterial, protozoal and helminthic GE occur, particularly in developing countries. Vomiting and diarrhoea can be nonspecific symptoms in children, and the diagnosis of viral GE should be made after careful exclusion of other causes.