Publications by authors named "Annabelle Lobermeyer"
Applications of Nanopore sequencing in precision cancer medicine.
Sergey A Dyshlovoy
,
Stefanie Paigin
,
Ann-Kristin Afflerbach
,
Annabelle Lobermeyer
,
Stefan Werner
Int J Cancer
December 2024
Article Synopsis
- Oxford Nanopore Technologies sequencing is revolutionizing clinical genetics by providing fast, long-read, and real-time DNA and RNA sequencing, making it more accessible and affordable.
- This review highlights its potential in precision cancer diagnostics and treatment, showcasing successful case studies where it identified key genetic markers that influenced treatment decisions.
- The article also discusses challenges in using Nanopore sequencing clinically and current efforts aimed at overcoming these obstacles.
Article Synopsis
- NK cells are crucial for fighting viral infections and use a variety of receptors, with HLA-C being the main ligand for Killer-cell immunoglobulin-like receptors (KIRs), influencing NK cell activity.
- The study shows that HIV-1 can evade the immune response by adapting to host genetics, particularly through the Vpu protein that downregulates HLA-C, which helps the virus escape detection by NK cells.
- Researchers found that HIV-1 infection leads to changes in the NK cell receptor profile, including an increase in specific NK cell populations and a genotype-dependent expansion of KIR2DL1, indicating a complex relationship between the immune response and HIV-1 evolution.
Article Synopsis
- The human leukocyte antigen (HLA) system is a group of diverse genes vital for immune function and linked to many diseases.
- HLA class I molecules, including the recently evolved HLA-C, present proteins to immune cells, influencing immune tolerance or responses during infections.
- HLA-C specifically interacts with killer-cell immunoglobulin-like receptors (KIR) on natural killer (NK) cells, which play a key role in fighting viral infections, highlighting HLA-C's importance in immune regulation.