The Anti-Angiogenic Effect of L. subsp. Waste Product.

L. subsp. ( L.

Exploring the chemical composition, the antioxidant, and the antiangiogenic potential of ancient onion (Allium cepa L.) varieties through molecular networks and chemometric tools.

Preserving plant biodiversity and making sustainable use of genetic resources in agriculture is a topical issue with ecological, economic, and social repercussions. In Italy, some onion (Allium cepa L.) varieties, only cultivated by local farmers, are neglected and worth to be valorised.

Re-discovering Prunus fruit varieties as antiangiogenic agents by metabolomic and bioinformatic approach.

In this work, a comparative chemical-biological study of nine plum varieties (Prunus domestica L. and Prunus salicina Lindl.) with two commercial ones was carried out to improve their cultivation and use in the agri-food chain.

Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes.

Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, , synthesized and characterized according to previously reported procedures.

New Insights on Phytochemical Features and Biological Properties of Stem Bark.

(namely black alder or European alder) is a tree of the Betulaceae family widely spread through Europe, Southeastern Asia, the Caucasus mountains, and Western Siberia. Its bark is traditionally used for medicinal purposes as an astringent, cathartic, febrifuge, emetic, hemostatic, and tonic, suggesting that it may contain bioactive compounds useful to counteract inflammation. The aim of this study was to investigate the phytochemical profile of stem bark extract (AGE) by LC-DAD-ESI-MS/MS analysis and to validate some biological activities such as antioxidant, anti-inflammatory and anti-angiogenic properties by in vitro and in vivo models (chick chorioallantoic membranes and zebrafish embryos), that can justify its use against inflammatory-based diseases.

Design, Synthesis, and in Vitro Evaluation of 4-(4-Hydroxyphenyl)piperazine-Based Compounds Targeting Tyrosinase.

Melanin biosynthesis is enzymatically regulated by tyrosinase (TYR, EC 1.14.18.

Ziziphus lotus (L.) Lam. as a Source of Health Promoting Products: Metabolomic Profile, Antioxidant and Tyrosinase Inhibitory Activities.

The methanolic extract of the stem bark of a wild species of jujube, Ziziphus lotus (L.) Lam., growing in Sicily, was chemically and biologically investigated.

[Mobbing: between personality traits and organizational-managerial characteristics of the occupational environment].

Unlabelled: INTRODUCTION. The relationship between stressful events in the workplace and their effect on health is the subject of numerous studies where the phenomenon of"Mobbing" has become of increasing interest in Social Psychiatry and Occupational Medicine. The aim of this study is to evaluate the relationship between mobbing, occupational stress and personality structure in a group of persons who consulted the "Work Adaptation Disorders Centre" at the Institute of Occupational Medicine between December 2008 and June 2010 for mobbing-related issues.

Chlamydophila psittaci seropositivity and serum levels of soluble intercellular adhesion molecule-1 in farmers.

Chlamydophila infection is known as an occupational hazard to veterinarians, farmers, poultry workers. Serum levels of the soluble Intercellular Adhesion Molecule-1 (sIC AM-1), is associated with C. seropositivity.

Serologic investigation of the prevalence of Chlamydophila psittaci in occupationally-exposed subjects in eastern Sicily.

The aim of the study was to investigate the occurrence of serum antibodies to C. psittaci in workers at 8 stock farms located in a rural area of eastern Sicily. Serum samples from 188 workers and 160 controls were tested for immunoglobulin IgA, IgG and IgM direct against C.

[Burnout and occupational stress in nurses].

Background: In the last few years there has been a growing interest in the psychosocial work environment of health care workers, since they are both at high risk of burnout, role conflict and job dissatifaction. Burnout, as a type of prolonged response to chronic job-related stress, has a special significance in health care settings, where staff experience both psychological--emotional and physical stress.

Objectives: The present study investigated the interrelationship between burnout, occupational stress and personality characteristics in a sample of 120 nurses employed in the Infectious Diseases Department and the Department of Medical Oncology of two major hospitals in Messina, Italy.

Relationship of blood lead levels to blood pressure in exhaust battery storage workers.

Several researches has focused the hypothesis that low blood lead levels could be associated with an increased risk of hypertension. To assess the relation between occupational lead exposure and elevated blood pressure a group of 27 workers, age range from 27 to 62 years, mean (SD) 36.52 (+/- 8.

Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents.

Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects.

[Serologic investigation on the prevalence of Leptospira spp infection in occupationally exposed subjects].

Background: Leptospirosis is a worldwide zoonotic infection with a high in tropical regions.

Objective: The aim of the present survey was to verify the occurrence of diffusion of leptospirosis infections in Eastern Sicily, in some groups (6 veterinarians, 34 farmers and 28 abattoir workers), who were considered at high occupational risk.

Methods: Serologic investigation were performed using the immunological method (Martin Petit test); the Leptospira serovars considered were: ictero-haemorrhagiae (Bianchi 1); canicola (Alarik); pomona (Mezzano 1); grippo-typhosa (Moskva V); bratislava (Riccio 2); sejroe (Topino 1); hardjo (Hardjoprajitno); saxkoebing (Mus 24).