Oxidized Phosphatidylcholines Activate NOX1-Mediated Oxidative Stress Response and Shift Glucose Metabolism in Cardiac Cells.

In cardiometabolic syndrome the development of cardiovascular disease is linked with an increase in systemic oxidative stress. The formation of free radical species leads to the oxidative modification of lipids, including phosphatidylcholines (OxPCs), which have been implicated in the progression of cardiovascular diseases in humans. We found that reducing plasma levels of OxPCs in mice by AAV-mediated hepatic expression of an OxPC-targeting antibody fragment (scFv-E06), resulted in significant transcriptional changes in the heart, particularly affecting genes involved in metabolism, redox processes, and fibrosis.