3D printed vasculogenic pectin-fucoidan scaffold containing sildenafil-loaded nanomicelles promoted diabetic wound healing.

Chronic diabetic wounds are marked by impaired angiogenesis, persistent inflammation, and delayed tissue regeneration, making them a critical challenge in clinical practice. Effective healing requires biomaterials that restore vascularization and support cell proliferation and growth. In this context, a 3D-printed scaffold composed of pectin (Pec) and fucoidan (Fc) was fabricated and integrated with sildenafil-loaded nanomicelles (Sf.

Three-dimensional printed polyelectrolyte construct containing mupirocin-loaded quaternized chitosan nanoparticles for skin repair.

Despite substantial advancements in wound dressing development, effective skin repair remains a significant challenge, largely due to the persistent issue of recurrent infections. Three-dimensional printed constructs that integrate bioactive and antibacterial agents hold significant potential to address this challenge. In this study, a 3D-printed hydrogel scaffold composed of polyallylamine hydrochloride (PAH) and pectin (Pc), incorporated with mupirocin (Mp)-loaded quaternized chitosan nanoparticles (QC NPs) was fabricated.