Chewing Dystonia and Sensory Modulation: An Exploratory Study of Intraoral Lidocaine Effects.

Background: Chewing dystonia is a rare, task-specific oromandibular dystonia that causes involuntary jaw and tongue movements during mastication and often refractory to standard treatments for dystonia. Emerging evidence suggests that peripheral sensory modulation may play a role in dystonia pathophysiology, but this has not been systematically evaluated as potential treatment modality.

Objectives: The aim of this study was to explore the therapeutic and neurophysiological effects of intraoral topical lidocaine in patients with task-specific chewing dystonia.

Functional Neurological Disorders: A Comprehensive Review.

Functional neurological disorders (FNDs) are altered voluntary symptoms incompatible with recognized medical or neurological conditions, causing significant distress to the patient. It is not a diagnosis of exclusion, but positive signs must be used to make a confident diagnosis and initiate appropriate management at the earliest. The understanding of FNDs has evolved over decades from supernatural power in the Mesopotamian age to the current neurocircuitry dysfunction and yet continues to be an area of active research.

Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

Background: Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions are characterized by rapid progression, poor prognosis, low survival rates, and limited treatment options. Few studies have suggested that genetic, environmental factors and inflammation contribute to the pathobiology of these complex disorders, however, the etiology of disease and progression remains unclear.

Prevalence, Risk Factors, and Psychosocial Impact of Restless Legs Syndrome in End-Stage Renal Disease Patients Undergoing Hemodialysis - A Cross-Sectional Study.

Background And Objectives: Restless legs syndrome (RLS) is common but often underdiagnosed in patients with end-stage renal disease (ESRD) undergoing hemodialysis, significantly impacting their quality of life. This study investigates the prevalence, risk factors, and psychosocial effects of RLS in this population.

Methods: A cross-sectional study was conducted among 308 hemodialysis patients at a tertiary care hospital.

Assessment of social isolation and changes in Parkinson's disease symptoms during the COVID-19 pandemic: A longitudinal study.

Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.

Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).

Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions.

Unravelling Heterogeneity: A Rare PNPT1 Variant in Childhood-Onset Spinocerebellar Ataxia with Sensorineural Hearing Loss.

Spinocerebellar ataxias (SCAs) are a diverse and heterogeneous group of inherited neurodegenerative disorders marked by progressive ataxia and cerebellar degeneration. This case report details an 11-year-old Indian boy with childhood-onset ataxia and severe sensorineural hearing loss, a rarely reported concomitance in pediatric neurology. Genetic analysis identified a unique heterozygous 3' splice site variant in the PNPT1 gene (c.

Parkinson's disease subtypes: Approaches and clinical implications.

Parkinson's disease (PD) is a complex neurodegenerative disorder with significant heterogeneity in disease presentation and progression. Subtype identification remains a top priority in the field of PD clinical research. Several PD subtypes have been identified.

Garba Dance Is Effective in Parkinson's Disease Patients: A Pilot Study.

Background: Dance as therapy is gaining attention as an adjuvant option for Parkinson's disease (PD). Assessing culturally popular dance forms is crucial for promoting the acceptance of dance therapy in a culturally sensitive context.

Objectives: The pilot study evaluated the efficacy of Garba dance for alleviating motor symptoms, nonmotor symptoms, cognitive functions, and mood.

Clinico- Radiological Profile and Outcome of Isolated Paramedian Hemipontine Infarcts.

Objective: To study the clinico- radiological profile and outcome of isolated paramedian hemipontine infarcts.

Materials And Methods: This is a prospective cross- sectional study. 50 consecutive patients admitted between January 2019 and December 2020 with a diagnosis of isolated paramedian hemipontine stroke were included.

Study of cerebrospinal fluid levels of lactate, lactate dehydrogenase and adenosine deaminase in the diagnosis and outcome of acute meningitis.

Background: Meningitis is a serious clinical health issue in most developing countries. Late diagnosis and treatment result in significant morbidity and mortality. This research aims to study the utility of CSF lactate, lactate dehydrogenase (LDH), and adenosine deaminase (ADA) as diagnostic markers in acute meningitis, and to differentiate among varied aetiologies of acute meningitis and their outcomes.

Surgical Outcome of Encephaloduroarteriomyosynangiosis for Moyamoya Disease.

Objective: Indirect bypass surgeries for moyamoya disease have included modifications of procedures involving placement of the superficial temporal artery on the brain pial surface. We evaluate the functional and angiographic outcomes of patients treated with encephaloduroarteriomyosynangiosis (indirect) revascularization and examine the outcome in relation to demographic and radiological factors.

Materials And Methods: Patients treated surgically for moyamoya disease over a 14-year period were identified.

Electrophysiological Evaluation of Audiovestibular Pathway Dysfunction in Parkinson's Disease and Its Correlates: A Case Control Study.

Background: Parkinson's disease (PD) is associated with brainstem dysfunction causing non-motor symptoms. Vestibular evoked myogenic potential (VEMP) and brainstem auditory evoked potential (BAEP) are electrophysiological tests to assess the vestibular and auditory pathways in the brainstem.

Objectives: To study the abnormalities of cervical VEMP (cVEMP) and BAEP in PD and to correlate the findings with the symptoms related to brainstem involvement.

Rash Decisions in Neurology: A Case Report of Brachioradial Pruritus Secondary to Cervical Intramedullary Lesion.

Brachioradial pruritus (BRP) is an enigmatic condition often encountered by dermatologists and passed off as a benign itch. It is an "idiopathic" pruritus, presenting as severe itching on the radial aspect of the elbow. The physical examination may be unremarkable except for mild pruritic lesions.

Deep Cerebral Venous Thrombosis-A Clinicoradiological Study.

Stroke is a common neurological emergency. Almost 80% of strokes are due to arterial occlusion. Venous thrombosis comprises less than 1-2% of all strokes.

Study of Short Latency Somatosensory and Brain Stem Auditory Evoked Potentials Patients with Acute Ischemic Stroke Involving Middle Cerebral Artery Territory.

 The precise timings of evoked potentials in evaluating the functional outcome of stroke have remained indistinct. Few studies in the Indian context have studied the outcome of early prognosis of stroke utilizing evoked potentials.  The aim of this study was to determine somatosensory evoked potentials (SSEPs) and brain stem auditory evoked potentials (BAEPs), their timing and abnormalities in acute ischemic stroke involving the middle cerebral artery (MCA) territory and to correlate SSEP and BAEP with the functional outcome (National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale (mRS) and Barthel's index) at 3 months.

A Case of Possible IgG4-Related Disease with Bilateral Optic Neuropathy and Bilateral Hippocampal Bleed.

IgG4-related disease (IgG4-RD) is a multisystem inflammatory disorder. The diagnosis requires consideration of clinical, radiographic, serological, and pathological evidence. Neurological involvement by IgG4-RD is relatively uncommon and is being increasingly recognized and reported with hypertrophic pachymeningitis and hypophysitis as the most frequent manifestations.

Role of High Frequency Oscillations of Somatosensory Evoked Potentials in Deciphering Pathophysiology of Migraine.

 Habituation deficit is considered as a neurophysiological abnormality among migraineurs in the interictal period. For clear comprehension and clarity about the mechanism underlying habituation in migraine, a sophisticated method, i.e.

Acute Hydrocephalus in a Case of Mumps Meningoencephalitis: A Rare Occurrence.

Mumps is an acute viral illness, which presents with glandular and/or nervous system involvement. The most common central nervous system manifestations of mumps include aseptic meningitis and meningoencephalitis. Mumps meningoencephalitis, which is characterized by fever, vomiting, nuchal rigidity, and altered sensorium, usually develops at least 3-10 days after mumps parotitis.

Transcranial Doppler for Monitoring and Evaluation of Idiopathic Intracranial Hypertension.

 Idiopathic intracranial hypertension (IIH) is a disorder of unknown origin, characterized by features of raised intracranial pressure (ICP). Existing literature is inconclusive about the role of transcranial Doppler (TCD) in the management of IIH.  To study the TCD changes in IIH patients, pre- and post-cerebrospinal fluid (CSF) drainage.