Hematopoietic Stem Cell (HSC) Graft Cryopreservation Effects on Outcomes of Patients with Hematologic Malignancies: the Multicenter United Kingdom Experience During the COVID-19 Pandemic.

The effects of graft cryopreservation on patient outcomes in allogeneic hematopoietic cell transplantation (HCT) remains unclear. In our multicenter UK study, outcomes of 926 adults receiving an allogeneic cryopreserved peripheral blood stem cell (PBSC) graft for a malignant hematologic indication between June 2020 and September 2021 were compared with 1491 adults with hematologic malignancy transplanted June 2018 to September 2019 with fresh PBSC grafts. There were short delays in median platelet and neutrophil engraftment with cryopreserved hematopoietic stem cell (HSC) grafts: 18 versus 15 days (P < .

Genetic Findings of Potential Donor Origin following Hematopoietic Cell Transplantation: Recommendations on Donor Disclosure and Genetic Testing from the World Marrow Donor Association.

Following hematopoietic cell transplantation (HCT), recipients are subjected to extensive genetic testing to monitor the efficacy of the transplantation and identify relapsing malignant disease. This testing is increasingly including the use of large gene panels, which may lead to incidental identification of genetic and molecular information of potential donor origin. Deciphering whether variants are of donor origin, and if so, whether there are clinical implications for the donor can prove challenging.

Favorable recovery profiles and good reliability among youngest unrelated stem cell donors supports lowering the minimum donor registration age.

Introduction: Younger donor age in hematopoietic cell transplantation has been associated with improved overall and disease-free survival. Safety data on peripheral blood stem cell (PBSC) and bone marrow (BM) donation is well established, including in the <18-year old age group in the related setting. In response, Anthony Nolan became the first stem cell donor registry to lower the minimum age for unrelated donors to 16-years.

High lactate dehydrogenase at time of admission for allogeneic hematopoietic transplantation associates to poor survival in acute myeloid leukemia and non-Hodgkin lymphoma.

Risk stratification is important for balancing potential risks and benefits of allogeneic hematopoietic stem cell transplantation (HSCT) for hematological malignancies. We retrospectively studied 1119 patients undergoing allogenic-HSCT in a single center for five hematological indications assessing the prognostic role of LDH at admission for survival (OS), progression-free survival (PFS), relapse incidence (RI), and nonrelapse mortality (NRM). In non-Hodgkin lymphoma (NHL) and acute myeloid leukemia (AML), higher than median LDH had an adverse effect on survival.