Publications by authors named "Angelo D Palmas"
Article Synopsis
- Italy faced the SARS-CoV-2 outbreak unevenly, with Sardinia having one of the lowest incidence rates, potentially due to its insular characteristics.
- The study analyzed 2,327 SARS-CoV-2 genomes collected from Sardinia to investigate genetic diversity and evolutionary patterns over three years.
- Findings indicate that Sardinia experienced unique COVID-19 trends, including the introduction of rare viral lineages caused by tourism and its geographic isolation, affecting the spread of common variants.
The prognostic impact of achieving and in particular maintaining measurable residual disease (MRD) negativity in multiple myeloma is now established; therefore, identifying among MRD-negative patients the ones at higher risk of losing MRD negativity is of importance. We analyzed predictors of unsustained MRD negativity in patients enrolled in the FORTE trial (NCT02203643). MRD was performed by multiparameter flow cytometry (sensitivity of 10-5) at premaintenance and every 6 months thereafter.
View Article and Find Full Text PDFBackground: The SARS-CoV-2 pandemic stimulated an outstanding global sequencing effort, which allowed to monitor viral circulation and evolution. Nuoro province (Sardinia, Italy), characterized by a relatively isolated geographical location and a low population density, was severely hit and displayed a high incidence of infection.
Methods: Amplicon approach Next Generation Sequencing and subsequent variant calling in 92 respiratory samples from SARS-CoV-2 infected patients involved in infection clusters from March 2020 to May 2021.
Early Diffusion of SARS-CoV-2 Infection in the Inner Area of the Italian Sardinia Island.
Front Microbiol
February 2021
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for the coronavirus disease 2019 (COVID-19) pandemic, which started as a severe pneumonia outbreak in Wuhan, China, in December 2019. Italy has been the first European country affected by the pandemic, registering a total of 300,363 cases and 35,741 deaths until September 24, 2020. The geographical distribution of SARS-CoV-2 in Italy during early 2020 has not been homogeneous, including regions severely affected as well as administrative areas being only slightly interested by the infection.
View Article and Find Full Text PDFBackground: Aberrant DNA methylation of promoter region CpG islands is an alternative mechanism that leads to genetic defects in the inactivation of tumor suppressor genes during myelomagenesis. The aim of this study was to examine the promoter methylation status of the phosphates and tensin homologue on chromosome 10 (PTEN) gene in a cohort of multiple myeloma patients.
Findings: The PTEN gene was hypermethylated in 7 out of 58 (12%) primary myeloma samples.