Relationship between pain, quality of sleep, sleep bruxism and patients' personality among individuals with reported orofacial pain.

The study aimed to determine the relationship between personality traits, orofacial pain (OFP), and headache. Eligible patients underwent one-night videopolysomnography and completed a series of validated questionnaires assessing sleep quality (ISS- Insomnia Severity Scale, PSQI- Pittsburgh Sleep Quality Index, ESS- Epworth Sleepiness Scale), pain intensity (McGill Pain questionnaire, GCPS- Graded Chronic Pain Scale, HIT-6- Headache Impact Test-6, MIDAS- Migraine Disability Assessment, TMD pain screener- Temporomandibular Disorder pain screener), psychoemotional state (KPS- Sense of Stress Questionnaire, PHQ-9 - Patient Health Questionnaire-9, BDI- Beck Depression Inventory, BAI- Beck Anxiety Index, PSS-10- Perceived Stress Scale-10, GAD-7- Generalized Anxiety Disorder-7), personality traits (IPIP-BFM-20 -International Personality Item Pool- Big Five Markers- 20). Patients who exhibited nervousness and hypersensitivity reported higher perceived pain and greater negative impacts on work and daily activities (p = 0,000).

Bleomycin-loaded folic acid-conjugated nanoliposomes: a novel formulation for targeted treatment of oral cancer.

Introduction: Targeted delivery of anticancer drugs holds great promise for enhancing therapeutic efficacy while minimizing adverse effects. The folate receptor (FR)-mediated approach offers a selective strategy to target cancer cells overexpressing FR. Bleomycin, an established antitumor antibiotic, suffers from limited efficacy due to poor diffusion into tumor cells.

Enhancing Cisplatin Delivery via Liposomal Nanoparticles for Oral Cancer Treatment.

Investigating the impact of liposomal Cisplatin on oral cancer cell line seeks to optimize drug delivery efficiency, decrease systemic toxicity, and amplify cytotoxicity specifically against malignant cells. Cisplatin was encapsulated within liposomal nanoparticles through thin-film hydration and extrusion methodologies. The physical and chemical characteristics of the nanoparticles, including zeta potential, size, drug load, and polydispersity index (PDI), were examined to evaluate their properties.

Enhanced antimicrobial efficacy and biocompatibility of albumin nanoparticles loaded with Mentha extract against methicillin resistant Staphylococcus aureus.

In an effort to combat methicillin-resistant Staphylococcus aureus (MRSA), this study investigates the potential of mentha-loaded albumin nanoparticles (MLAN) as a novel antimicrobial agent. MLAN was synthesized by a desolvation method in which the mentha extract was encapsulated in albumin nanoparticles to increase stability and reduce toxicity. Characterization of the nanoparticles by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and X-ray Diffraction (XRD) confirmed their spherical morphology, a size range of 100-200 nm and uniform distribution.

Combination Therapy of Curcumin and Cisplatin Encapsulated in Niosome Nanoparticles for Enhanced Oral Cancer Treatment.

Oral cavity cancer poses a significant health threat due to its aggressive nature and limited responsiveness to traditional therapies like chemotherapy and radiation, highlighting the need for more effective treatment options. To address this, researchers have explored a novel approach using niosome nanoparticles to co-encapsulate curcumin (CUR) and cisplatin (Cis), to enhance therapeutic efficacy. While CUR has anti-cancer properties, its poor bioavailability limits its effectiveness.

Prevalence of central sensitization and somatization in adults with temporomandibular disorders-a prospective observational study.

Temporomandibular disorders (TMD) comprise a group of conditions affecting the masticatory muscles, the temporomandibular joints and associated structures, often manifesting as orofacial pain and functional limitations of the mandible. Central sensitization (CS) is gaining increasing attention in research focused on pain syndromes and somatization, playing a significant role in the pain experience. This study investigates the prevalence of CS and somatization among TMD patients, analyzing their relationships with TMD diagnoses and the intensity of chronic masticatory muscle pain (MMP).

Applications of artificial intelligence in regenerative dentistry: promoting stem cell therapy and the scaffold development.

Tissue repair represents a critical concern within the domain of dentistry. On a daily basis, countless individuals seek dental clinic services due to inadequate dental care. Many of the treatments that patients receive have unfavorable side effects.

Tetracalcium Phosphate/Monetite/Calcium Sulfate Hemihydrate Biocement for Alveolar Bone Augmentation After Tooth Extraction in Pig Mandible.

A tetracalcium phosphate/monetite/calcium sulfate hemihydrate powder cement mixture (CAS) in the form of a paste was used as a socket preservative to prevent alveolar ridge resorption after the extraction of the second premolar tooth in the mandible of a pig model. During the post-surgery period, the animals were monitored daily. No signs of inflammation, infection, or other complications were observed in the defect site for six months.

From defense to offense: antimicrobial peptides as promising therapeutics for cancer.

Antimicrobial peptides (AMPs), naturally occurring components of innate immunity, are emerging as a promising new class of anticancer agents. This review explores the potential of AMPs as a novel class of anticancer agents. AMPs, naturally occurring peptides with broad-spectrum antimicrobial activity, exhibit several characteristics that make them attractive candidates for cancer therapy, including selectivity for cancer cells, broad-spectrum activity, and immunomodulatory effects.

Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy.

Natural products have proven to be promising anti-cancer agents due to their diverse chemical structures and bioactivity. This review examines their central role in cancer treatment, focusing on their mechanisms of action and therapeutic benefits. Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids and polyphenols, which exhibit various anticancer properties.

A Narrative Review on the Promising Potential of Graphene in Vaccine Design: Evaluating the Benefits and Drawbacks of Carbon Nanoplates in Nanovaccine Production.

Graphene, a two-dimensional material consisting of a single layer of carbon atoms arranged in a honeycomb lattice, has shown great potential in various fields, including biomedicine. When it comes to vaccine development, graphene can offer several advantages due to its unique properties. Potential applications of graphene in vaccine development include improved vaccine delivery, adjuvant properties, improved vaccine stability, improved immune response, and biosensing capabilities.

Comparative Analysis of Osteoblastic Responses to Titanium and Alumina-Toughened Zirconia Implants: An In Vitro Study.

Introduction: Osteoblastic responses play a crucial role in the success of oral implants. Enhanced proliferation of osteoblast cells is associated with reduced cell mortality and an increase in bone regeneration. This study aims to evaluate the osteoblastic responses following oral implantation.

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review.

Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells and targeted 3D scaffolds have been investigated in the search for workable solutions. The use of scaffolds in stem cell-assisted bone regeneration is a crucial component of tissue engineering techniques designed to overcome the drawbacks of traditional bone grafts.

Peculiarities of treatment of maxillofacial polytrauma during wartime.

Objective: Aim: Analyzing of the last-time papers in this subject in organizing, diagnostic and surgery tactic is the aim of this work.

Patients And Methods: Materials and Methods: The study analyzed the experience of treating patients with maxillofacial polytrauma before and after February 24, 2022. Research methods: bibliographic, systematic, comparative, general clinical, radiological and retrospective analysis.

Clinical and laboratory assessment of the state of periapical tissues in systemic lupus erythematosus.

Objective: Aim: To evaluate changes in clinical and laboratory parameters in patients with SLE depending on the severity and activity of the disease.

Patients And Methods: Materials and Methods: The study included 50 patients with SLE of different age groups, 10 men and 40 women.

Results: Results: Systemic lupus erythematosus (SLE) is a chronic disease that belongs to the group of rheumatic diseases and is characterised by autoimmune tissue damage.

Relationship between pain severity, satisfaction with life and the quality of sleep in Polish adults with temporomandibular disorders.

Background: Temporomandibular disorders (TMD) pose a serious health problem that can have a negative effect on patients' lives, impair work performance, and result in work absences and restrictions in daily activities.

Objectives: The aim of this observational, cross-sectional study was to evaluate the level of satisfaction with life among Polish patients with TMD and to assess the influence of pain severity on this parameter. A secondary goal was to investigate sleep quality within this patient group and explore its relationship with pain.

Sleep-related rhythmic movement disorder in adults - A systematic review with a case report.

Sleep-related rhythmic movement disorder is characterised by stereotyped and repetitive rhythmic movements involving large muscle groups during sleep with frequencies between 0.5 and 2 Hz. Most of the published studies on sleep-related rhythmic movement disorder have focussed on children.

Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An Study.

Reconstruction of bone defects and maintaining the continuity of the mandible is still a challenge in the maxillofacial surgery. Nowadays, the biomedical research within bone defect treatment is focussed on the therapy of using innovative biomaterials with specific characteristics consisting of the body's own substances. Hydroxyapatite ceramic scaffolds have fully acceptable phase compositions, microstructures and compressive strengths for their use in regenerative medicine.

Efficiency of occlusal splint therapy on orofacial muscle pain reduction: a systematic review.

Background: This systematic review aims to examine the existing original studies to determine the effectiveness of occlusal splints (OSs) in the management of orofacial myalgia and myofascial pain (MP) in comparison with no treatment or other interventions.

Materials And Methods: Based on the inclusion and exclusion criteria of this systematic review, randomized controlled trials were qualified, in which the effectiveness of occlusal splint therapy in the management of muscle pain was examined in comparison with no treatment or other interventions. This systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020.

Determination of pain intensity, pain-related disability, anxiety, depression, and perceived stress in Polish adults with temporomandibular disorders: A prospective cohort study.

Background: There is a need to assess a relationship between the psychoemotional state of patients and the occurrence and the intensity of pain and temporomandibular disorders (TMD) in relation to a Polish population. There are no such precision data in the literature relating to the population of big Eastern European country. The study conducted by the authors refer to a large group of male and female adult patients of the Polish population in a different age profile.

Genetically modified rodent models and celiac, non-celiac gluten sensitivity: a minireview.

Celiac disease (CD) is a disorder that affects both children and adults. Over the few last decades, several new atypical cases have been identified through improved diagnostic tools. On the other hand, the onset of CD at a later age, including atypical CD forms whose clinical picture overlaps with other autoimmune diseases, shows that currently there are several unknown gene mutations, which could be responsible for the disease development.

West Nile virus - a new infection in the Slovak Republic?

Objective: The aim of the study was to evaluate the seroprevalence of West Nile virus (WNV) among the variable population of Eastern Slovakia.

Methods: A serologic survey was conducted using 464 serum samples. The basic demographic, epidemiologic and clinical information was obtained for each serum sample at the time of specimen collection.

Effectiveness of primary vaccination against tick-borne encephalitis in employees of the armed forces.

Objective: The aim of our study is to evaluate immune response after receiving the primary vaccination against tick-borne encephalitis (TBE), and to establish a link between seropositivity and selected factors in soldiers.

Methods: Blood samples, questionnaires and vaccination records were obtained. TBE antibodies were detected using both ELISA and a neutralization test (NT).