Publications by authors named "Andrea D Tissera"

Introduction: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide, which has been suggested to induce male urogenital inflammation and affect fertility. However, reported evidence is scarce and inconclusive. Moreover, the putative effects of coinfections remain largely unexplored.

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Article Synopsis
  • - Human Papillomavirus (HPV) includes high-risk (HR-HPV) types linked to cancer and low-risk (LR-HPV) types associated mostly with benign warts, but their impact on male fertility is not well understood.
  • - A study involving 205 men found HPV in 19% of semen samples, with HR-HPV being more common; however, neither HR-HPV nor LR-HPV significantly affected overall sperm quality.
  • - HR-HPV+ men had higher sperm necrosis and reactive oxygen species levels, but surprisingly showed lower inflammation markers compared to controls, highlighting a need for HPV screening in fertility clinics to assess reproductive health risks.
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COVID-19 is known to have deleterious effects on different systems such as the respiratory, cardiovascular, central nervous, and gastrointestinal. However, conflicting data about the possible implications for male reproductive health and fertility have been reported. In addition, the long-term consequences of SARS-CoV-2 infection remain unclear.

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COVID-19 exerts deleterious effects on the respiratory, cardiovascular, gastrointestinal, and central nervous systems, causing more severe disease in men than in women. However, cumulative reported data about the putative consequences on the male reproductive tract and fertility are controversial. Furthermore, the long-term effects of SARS-CoV-2 infection are still uncertain.

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  • The text discusses a case involving an obligate intracellular pathogen responsible for sexually transmitted infections (STIs), specifically lymphogranuloma venereum (LGV), which typically presents with specific symptoms in men but can manifest atypically, as shown in the report.
  • The patient, a 36-year-old heterosexual male from Argentina, experienced intermittent testicular pain but did not display the conventional signs of LGV, leading to a unique clinical presentation that affected his sperm health.
  • Treatment with doxycycline resulted in microbiological cure and improved semen quality, highlighting the atypical nature of the infection while identifying LGV L2 as the causative agent.
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  • The study found that 17% of men had U. urealyticum and 23.6% had M. hominis, with 3.8% having both infections, regardless of their infertility status.
  • Infections were linked to higher levels of inflammatory cytokines (like TNF, IL-1β, and IL-6) and total leukocyte counts, which were associated with reduced sperm quality, suggesting a negative impact on male fertility potential.
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The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort of 117 male partners of infertile couples from Cordoba, Argentina. Semen samples and urethral swabs were obtained and the infection with HPV, Chlamydia trachomatis, HSV1, HSV2, Mycoplasma hominis and Ureaplasma urealyticum was analyzed. A prevalence of HPV infection of 27.

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Female and male infertility have been associated to Chlamydia trachomatis, Ureaplasma spp. and Mycoplasma hominis urogenital infections. However, evidence from large studies assessing their prevalence and putative associations in patients with infertility is still scarce.

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Spermatogenesis is a temperature-dependent process, and high summer temperatures have been linked to lower sperm concentration and count. However, reports describing the association between other meteorological variables and semen quality are scarce. This study evaluated the association between semen quality and temperature, humidity, pressure, apparent temperature (AT), temperature-humidity index (THI), simplified wet-bulb global temperature (sWBGT), and sunshine duration.

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Objective: To assess the impact of aging on routine semen and computer-assisted sperm analysis (CASA) motility parameters according to the current World Health Organization guidelines; and to evaluate the effect of obesity and lifestyle (alcohol consumption, cigarette smoking) in older men's semen.

Design: Blind cross-sectional study.

Setting: Research laboratory and andrology and reproduction laboratory.

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Problem: Antisperm antibodies (ASA) are associated with male subfertility. However, results on sperm surface autoantibodies are controversial, the relationship between ASA and semen parameters (WHO, 2010) is unknown, and data on ASA and sperm kinematics are scarce.

Method Of Study: A retrospective study carried out in men undergoing routine semen analysis (WHO 2010), ASA evaluation (direct SpermMAR(™) (IgG) test), and computer-assisted sperm analysis (CASA).

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beta-Microseminoprotein (MSMB) is one of the most abundant proteins in human seminal plasma. The objectives of this study were: (1) to purify MSMB from seminal plasma (SP) and generate antibodies against the pure protein; (2) to investigate the interaction of MSMB with ejaculated spermatozoa and its possible effect on the spontaneous acrosome reaction (AR); and (3) to quantify MSMB content in SP and examine its relationship with the clinical sperm parameters. MSMB was purified from SP and its presence on the sperm surface was examined by indirect immunofluorescence using a specific polyclonal antibody.

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