Persisting neurobehavioral consequences of gestational exposure to cadmium and benzo[a]pyrene in rats.

Neurotoxic risks in the environment come from many toxicants, which are often found together in complex mixtures. However, nearly all experimental studies evaluate one chemical at a time. Neurobehavioral effects of developmental exposure to heavy metals such as cadmium (Cd) and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) have been well-studied, however their potential for non-additive or interactive effects are not well known.

Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish.

Developmental exposure to either polycyclic aromatic hydrocarbons (PAHs) or heavy metals has been shown to cause persisting and overlapping neurobehavioral effects in animal models. However, interactions between these compounds have not been well characterized, despite their co-occurrence in a variety of environmental media. In two companion studies, we examined the effects of developmental exposure to cadmium (Cd) with or without co-exposure to prototypic PAHs benzo[a]pyrene (BaP, Exp.

Embryonic exposure to PFAS causes long-term, compound-specific behavioral alterations in zebrafish.

Per- and polyfluoroalkyl substances (PFAS) are commonly used as surfactants and coatings for industrial processes and consumer products. These compounds have been increasingly detected in drinking water and human tissue, and concern over their potential effects on health and development is growing. However, relatively little data are available for their potential impacts on neurodevelopment and the degree to which different compounds within this class may differ from one another in their neurotoxicity.