Biodegradable concanavalin A functionalized polycaprolactone nanoparticle: A promising avenue for cancer therapy.

Objective: Receptor-based tumor-selective delivery of therapeutic efficacy and therapeutic index of cytotoxic drugs that exhibit dose-limiting toxicity is observed. Concanavalin A (Con A) was selected as the ligand for the proposed system, which was appended to the polycaprolactone nanoparticles (NPs) carrying the drug to be a very efficient approach for the treatment of cancer.

Methods: Preparation of plain polycaprolactone nanoparticles was carried out employing the emulsion diffusion evaporation technique.

A Formulation of Paromomycin Sulphate as a Promising Fucose-Conjugated Nanostructured Lipid Carrier for Antileishmanial Drug Delivery.

Environmental and individual risk factors make leishmaniasis an important public health problem. Presently, there are several medicines existing for the cure of leishmaniasis, but a major problem associated with them is their adverse effects. The affinity to the fucose receptor increases the phagocytosis of ligand-bound carriers and simultaneously targets the delivery of the antileishmanial agent.