Serum Pentraxin 3 Fragment as a Noninvasive Marker of Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents.

Background/aims: It was suggested that serum pentraxin 3 (PTX3) levels could differentiate obese children with nonalcoholic steatohepatitis (NASH) from those with simple steatosis. Thus, we aimed to evaluate the clinical utility of serum PTX3 fragment levels in the diagnosis of NASH and the assessment of its severity in obese children with suspected nonalcoholic fatty liver disease (NAFLD).

Methods: Fifty obese children were compared to 25 matched controls.

Intestinal parasitic infection among Egyptian children with chronic liver diseases.

Patients with chronic liver diseases (CLD) are often highly susceptible to parasitic infection due to a depressed immune system. The objective of this study was to detect the most commonly intestinal parasites found among Egyptian children with CLD. The present study was conducted on 50 children with CLD of different etiology (25 were having different intestinal symptoms, 25 without intestinal symptoms) and 50 non-CLD children with gastrointestinal complaints served as controls.

Transfusion transmitted hepatitis: where do we stand now? A one center study in upper egypt.

Background: Despite progress made in the prevention of transfusion-transmitted infections (TTI) over the last few years, they continue to be a problem in many parts of the world, particularly in multitransfused patients.

Objectives: The aim of this study was to estimate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and to evaluate the screening and vaccination program among our cohort of multitransfused children from Qena, Upper Egypt.

Patients And Methods: One-hundred children suffering from diseases requiring repeated blood transfusions were included in the study.

Serum IL-6 and IL-8 in infants with biliary atresia in comparison to intrahepatic cholestasis.

Background: Biliary atresia (BA) is an idiopathic progressive inflammation and fibrosclerosis of the extra and intrahepatic bile ducts.

Aim: To measure the serum levels of IL-6 and IL-8 in biliary atresia and correlate with clinical outcome.

Methods: Sixty children were included, 20 with BA (group 1), 20 with intrahepatic cholestasis (group 2) and 20 normal children as controls.

HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection.

Background: The human leukocyte antigens (HLAs) are proteins found in the membranes of nearly all nucleated cells. People with certain HLA antigens are more likely to develop certain autoimmune diseases. The aim of this study was to determine the frequency of HLA-DRB1 in children with autoimmune hepatitis (AIH) as a risk factor for occurrence, its relation to preceding hepatitis A infection and treatment outcome.