Publications by authors named "Amber D Kimble"
Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1.
Acta Crystallogr F Struct Biol Commun
December 2024
Article Synopsis
- Onchocerca volvulus is responsible for serious health issues, including blindness and neurological diseases, and current treatments like ivermectin can't be safely used in pregnant women or those co-infected with Loa loa.
- Researchers at the Seattle Structural Genomics Center for Infectious Disease have successfully produced and crystallized a potential drug target called OvMIF-1, which has a unique jellyfish-like structure.
- The study suggests that deleting its N-terminal tag could reveal a larger cavity for drug targeting, indicating the need for further analysis to confirm the true biological structure of OvMIF-1.