Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish.

Neurological disorders are a major contributor to disability-adjusted life years (DALYs) worldwide, with anxiety and epilepsy being particularly prevalent. Among them, anxiety is among the top ten diseases and causes an annual cost of 42.3 billion dollars in the United States.

Hydrophobin-Fused SARS-CoV-2 RBD production in for COVID-19 serology.

Introduction: The global health crisis underscores the need for accessible and cost-effective biomedical solutions, especially in resource-limited settings. Plant-based transient expression systems provide a viable method for producing recombinant proteins, such as the SARS-CoV-2 receptor-binding domain (RBD), for diagnostic applications. The addition of hydrophobin enhances protein purification efficiency and cost-effectiveness.

Subcutaneous, Oral, and Intranasal Immunization of BALB/c Mice with K39 Antigen Induces Non-Protective Humoral Immune Response.

Visceral leishmaniasis is a high-burden disease caused by parasites of the genus. The K39 kinesin is a highly antigenic protein of , but little is known about the immune response elicited by this antigen. We evaluated the humoral immune response of female BALB/c mice ( = 6) immunized with the rK39-HFBI construct, formed by the fusion of the K39 antigen to a hydrophobin partner.