Publications by authors named "Alison B Claybon"
Article Synopsis
- BRCA2 is a tumor suppressor that helps prevent genome instability in normal tissues, but its role in non-cancerous cells has been less understood compared to its assessment in cancer cell models.
- The study used a specific mouse model to look at the effects of deleting a part of the BRCA2 gene, finding that this deletion led to a lower frequency of precise DNA repair events.
- The findings confirm that BRCA2 is essential for efficient DNA repair in normal tissues, indicating its critical role during normal cell development and proliferation.
The ability to detect and repair DNA damage is crucial to the prevention of various diseases. Loss of function of genes involved in these processes is known to result in significant developmental defects and/or predisposition to cancer. One such DNA repair mechanism, homologous recombination, has the capacity to repair a wide variety of lesions.
View Article and Find Full Text PDFWerner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members. WS cells exhibit genomic instability and altered proliferation, and in vitro studies suggest that WRN has a role in suppressing homologous recombination.
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