Publications by authors named "Aline Pertile Remor"
Cancer is a leading cause of mortality and morbidity worldwide and conventional chemotherapy frequently induce irreversible adverse effects in patients. Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of both paclitaxel (PTX) and oxaliplatin (OXA) chemotherapies, affecting approximately 30-50% of patients. As cancer survival rates have improved, the efforts of scientific community to develop new strategies for preventing CIPN are also growing.
View Article and Find Full Text PDFObjectives: To evaluate the efficacy of different methods of interfacial elastic compression and their association with obesity and chronic venous insufficiency (CVI).
Methods: Forty legs with vascular disease and 40 control legs were analyzed. Four different methods of elastic compression were applied and interface pressure was measured.
Assessing antioxidant responses in C6 and U-87 MG cell lines exposed to high copper levels.
Lara Stoeberl
,
Madson Silveira de Melo
,
Letícia Cordeiro Koppe de França
,
Lorena Aparecida de Souza
,
Roberta de Cássia Panazzollo
,
Aline Pertile Remor
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
Copper excess has been tested as an anticancer therapy, due to its properties to generate oxidative stress resulting in tumoral cell death. Thus, this study aimed to evaluate the impact of copper excess on oxidative stress and antioxidant responses in glioma cells, establishing the antioxidant system as a target of copper toxicity in tumoral cells. C6 and U-87 MG cells were exposed to CuSO (0-600 μM) for 24-48 h.
View Article and Find Full Text PDFArticle Synopsis
- Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant percentage of patients receiving paclitaxel, leading researchers to explore TZD-A1, a new potential treatment.
- The study involved various analyses to assess TZD-A1's interaction with PPARγ, its safety, and its effects on CIPN in mice, revealing a positive safety profile and effective reduction of neuropathy symptoms.
- Results suggest that TZD-A1 mitigates the negative effects of paclitaxel by preventing neuroinflammation and mitochondrial damage, making it a promising candidate for enhancing the quality of life in cancer patients.
Article Synopsis
- Manganese is a common element that's important for biological functions, but long-term exposure can lead to Manganism, a disorder similar to Parkinson's disease caused by mitochondrial issues and oxidative stress.
- This study explored the neuroprotective effects of probucol, a compound known for its anti-inflammatory and antioxidant properties, on brain slices from rats exposed to manganese chloride.
- Results showed that probucol effectively prevented manganese toxicity, maintaining cell viability and protecting mitochondrial function in the brain regions tested, highlighting its potential as an antioxidant therapy.
Neuroprotective Effect of Vitamin D on Behavioral and Oxidative Parameters of Male and Female Adult Wistar Rats Exposed to Mancozeb (manganese/zinc ethylene bis-dithiocarbamate).
Jessica Camile Favarin
,
Aline Basotti
,
Antuani Rafael Baptistella
,
Analu Mantovani
,
Marcos Freitas Cordeiro
,
Aline Pertile Remor
Mol Neurobiol
July 2023
Article Synopsis
- Exposure to the pesticide Mancozeb (MZ) poses significant public health risks, causing various negative effects such as hormonal, behavioral, and neurodegenerative issues linked to oxidative stress.
- * This study tested the protective effects of Vitamin D on male and female Wistar rats exposed to MZ, finding that MZ increased manganese levels in certain brain regions and caused behavioral changes, particularly in females.
- * Administration of Vitamin D successfully mitigated the damage from MZ, suggesting its potential as a neuroprotective agent against pesticide-related brain impairments.
Article Synopsis
- Manganese is an essential metal for bodily functions, but excessive amounts can lead to neurotoxicity and a condition similar to Parkinson's known as manganism.
- This study explored the protective effects of probucol, an anti-inflammatory and antioxidant lipid-lowering agent, against manganese-induced toxicity in human neuroblastoma (SH-SY5Y) and glioblastoma (C6) cell lines.
- Results showed that while higher concentrations of manganese reduced cell viability, probucol effectively countered these effects by preventing mitochondrial dysfunction and lowering harmful reactive oxygen species (ROS) levels.
Article Synopsis
- - Oral cancer (OC) is often diagnosed late due to its lack of early symptoms and distinctive signs, leading to treatment challenges and poorer outcomes, highlighting the need for better early detection methods, particularly through salivary cytokines (SC) as potential biomarkers.
- - The study systematically reviewed literature from PubMed and Cochrane Library, focusing on case-control studies measuring SC in saliva of treatment-naïve patients, to evaluate their use as diagnostic tools for OC.
- - Results from 28 studies indicated that specific SC levels, especially IL-8 and IL-6, were significantly higher in OC patients compared to healthy individuals and those with other oral conditions, suggesting a potential for these cytokines in the early diagnosis of oral
Glyphosate-based herbicide impairs energy metabolism and increases autophagy in C6 astroglioma cell line.
Katriane Neto da Silva
,
Laura Garbin Cappellaro
,
Caroline Naomi Ueda
,
Luana Rodrigues
,
Aline Pertile Remor
J Toxicol Environ Health A
February 2020
Article Synopsis
- Glyphosate formulations have been linked to neurotoxicity, causing oxidative stress and mitochondrial dysfunction, but how they affect astrocytes is still uncertain.
- A study found that 24-hour exposure to glyphosate reduced cell viability, mitochondrial enzyme activity, and mitochondrial mass in rat astrocyte cells while increasing non-protein thiol levels and autophagy-related proteins.
- The results suggest that glyphosate may target mitochondria and creatine kinase, with increased autophagy and non-protein thiols possibly acting as protective responses against oxidative damage, but further research is needed to understand these mechanisms better.
Article Synopsis
- The study aimed to explore how different doses of photobiomodulation (PBM) affect mitochondrial respiratory complexes and energy metabolic enzymes in brain, muscle, and C6 glioma cells over various time intervals.
- C6 glioma cells were exposed to an AlGaInP laser at doses of 10, 30, and 60 J/cm² for different durations, followed by biochemical measurements on their energy metabolism.
- Results indicated that PBM enhances respiratory complex activities in a dose- and time-dependent manner, with significant increases observed in specific complexes across different cell types and conditions.
Sex differences in subacute manganese intoxication: Oxidative parameters and metal deposition in peripheral organs of adult Wistar rats.
Carine Raquel Richter Schmitz
,
Tuany Eichwald
,
Maria Victória Branco Flores
,
Karina Giacomini Varela
,
Analu Mantovani
,
Aline Pertile Remor
Regul Toxicol Pharmacol
June 2019
Article Synopsis
- Manganese (Mn) is essential for biological functions but becomes toxic when accumulated excessively, particularly impacting the central nervous system (CNS), with limited research on its effects in other tissues.
- This study examined how Mn exposure affects oxidative stress, metabolism, and Mn levels in peripheral organs of male and female Wistar rats, using various doses over a month-long period.
- The findings indicated that while Mn concentrations increased in organs (especially kidneys), there were significant sex-related differences in toxic effects, with males showing greater oxidative stress and altered metabolic responses compared to females, despite similar levels of Mn deposition.
Article Synopsis
- Developmental endochondral ossification relies on a steady blood supply from the embryonic vascular network, which can be disrupted by high levels of homocysteine (Hcy).
- In a study on chicken embryos, treatment with Hcy led to significant decreases in important vasculogenic factors (VEGF, VCAM-1, NOS3) and osteocalcin, indicating Hcy's detrimental effects on blood vessel formation and bone mineralization.
- Despite no observable differences in limb ossification area between Hcy-treated and untreated embryos, the findings highlight Hcy's toxicity by reducing critical proteins necessary for proper limb development during embryogenesis.
Article Synopsis
- * A study on rats revealed that prolonged high blood sugar levels impaired cognitive function by affecting brain signaling and promoting neurotoxicity.
- * The findings suggest that improving body weight and metabolic health could potentially reverse cognitive impairment and lower the risk of brain diseases later on.
Article Synopsis
- Interictal hypometabolism in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS) is detected using FDG-PET imaging, revealing that left-sided hypometabolism relates to verbal memory problems, while right-sided hypometabolism affects nonverbal memory.
- In a study comparing 32 surgically treated MTLE-HS patients to 21 healthy controls, the epilepsy patients scored significantly lower on several cognitive tests, indicating impaired memory and language functions.
- Despite exploring the relationship between mitochondrial enzyme activities and cognitive test performances, the study found no significant associations, suggesting that memory impairments in MTLE-HS are not linked to the measured enzymatic activities in the affected temporal lobe regions
Mitochondrial respiratory chain complex enzyme activities of limbic structures and psychiatric diagnosis in temporal lobe epilepsy patients: Preliminary results.
Camila Moreira Osório
,
Kátia Lin
,
Ricardo Guarnieri
,
Maria Emília Rodrigues de Oliveira Thais
,
Helena Dresch Vascouto
,
Aline Pertile Remor
CNS Neurosci Ther
August 2017
1,25(OH)2 vitamin D3 signalling on immature rat Sertoli cells: gamma-glutamyl transpeptidase and glucose metabolism.
J Cell Commun Signal
September 2017
Article Synopsis
- 1α,25-Dihydroxyvitamin D (1,25-D) plays a crucial role in male reproduction, as its deficiency leads to reduced fertility in rats.
- The study investigates how 1,25-D affects gamma-glutamyl transpeptidase (GGT) activity and Sertoli cell functions, revealing that it stimulates GGT through a mechanism that does not require new protein synthesis.
- Key findings show that 1,25-D enhances glucose uptake and lactate production in Sertoli cells while protecting them from death, highlighting its importance in supporting germ cell nutrition and spermatogenesis.
Article Synopsis
- Exercise can improve mental health and brain function in aging by influencing neurogenesis and neuroplasticity.
- A study on aged mice showed that physical activity reduced depressive-like behavior and improved motor skills while altering gene expression related to brain health.
- The findings suggest that regular exercise enhances brain-derived neurotrophic factor (BDNF) activity and the REST factor, while reducing inflammation, contributing to healthier aging in the brain.
Article Synopsis
- This study explored how early and long-term low-level laser therapy (LLLT) affects oxidative stress and inflammation after muscle injury in Wistar rats.
- Rats were divided into four groups to assess the impact of LLLT (at doses of 3 and 5 J/cm²) initiated shortly after inducing muscle trauma.
- Findings showed LLLT improved muscle recovery, reduced oxidative stress and inflammation, and restored normal locomotion, suggesting its benefits in managing acute muscle injuries.
Article Synopsis
- The study evaluated mitochondrial respiratory chain complex enzymatic activities in frozen brain samples from patients undergoing epilepsy surgery, which provided a unique opportunity to analyze human brain tissue directly.
- It found that various intra-operative parameters, such as mean arterial blood pressure and oxygen saturation, significantly influenced these enzymatic activities in different brain regions like the middle temporal neocortex, amygdala, and hippocampus.
- The research highlights the importance of controlling multiple factors, including seizure timing and sample storage, to reduce biases in future studies using human brain samples from elective neurosurgeries.
Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway.
Aderbal Silva Aguiar
,
Marcelo Duzzioni
,
Aline Pertile Remor
,
Fabrine Sales Massafera Tristão
,
Filipe C Matheus
Neurochem Res
February 2016
Article Synopsis
- Exercise helps improve motor symptoms in Parkinson's disease and shows neuroprotective properties due to its effect on mitochondrial function and oxidative stress.
- A study on C57BL/6 mice involved a 6-week treadmill exercise program after inducing hemiparkinsonism with a neurotoxin, which resulted in reduced motor deficits and activation of protective genes.
- The results indicated that exercise not only protected against the loss of important brain cells but also stimulated mitochondrial growth, potentially offering a protective mechanism against the disease.
Article Synopsis
- Human genetic research indicates a link between specific gene variations that lower BH4 levels and less pain in patients.
- In mice, excessive BH4 is produced by damaged sensory neurons and macrophages, which heightens pain sensitivity; however, blocking BH4 production in sensory neurons can reduce hypersensitivity after nerve injury without affecting normal pain responses.
- A newly developed inhibitor targeting sepiapterin reductase (SPR) successfully lowers pain sensitivity and BH4 levels in affected tissues, showing no side effects or tolerance development, and sepiapterin accumulation serves as an important biomarker for SPR inhibition.
Article Synopsis
- *Blood samples collected before and after the race showed significant increases in lactate dehydrogenase and creatine kinase, indicating muscle damage.
- *The investigation concluded that despite tissue damage, the increased oxidative metabolism may enhance endurance performance by improving substrate oxidation at the mitochondrial level.*
Article Synopsis
- Intensive antihyperglycemic treatment in diabetes can reduce serious complications, and this study looked at how insulin affects mitochondrial function in hyperglycemic rats.
- Hyperglycemic rats showed energy deficiencies in specific tissues, with the heart being the most affected, and insulin treatment helped reverse some of this damage.
- In vitro experiments indicated that oxidative stress from compounds like methylglyoxal and advanced glycation end products can harm mitochondria, suggesting the need for early and ongoing insulin therapy to protect mitochondrial function in diabetes.
Article Synopsis
- The study investigated the impact of pesticide exposure on farm workers in Rio Grande do Sul, Brazil, by measuring specific enzyme activities and DNA damage.
- Results showed significant reductions in butyrylcholinesterase (BChE) and delta-aminolevulinic acid dehydratase (ALA-D) activities among exposed workers compared to a control group.
- The analysis indicated elevated DNA damage in the exposed group but found no notable differences in hematological, lipid, or micronucleus test results based on age or smoking status; the use of personal protective equipment (PPE) appeared crucial for reducing contamination risk.