Synthesis, Antimicrobial and Antioxidant Activity With ADMET Prediction, Molecular Docking, and Dynamics Studies of Novel Thiazole-Schiff Base Derivatives.

Eleven thiazole-Schiff base derivatives 2a-2k were synthesized via a two-step synthetic route and elucidated by spectral analyses (infrared [IR], H NMR, C NMR, and HRMS). The in vitro antimicrobial activity of the synthesized thiazole derivatives was carried out against four gram-positive bacteria, two gram-negative bacteria, and two fungal strains. Compound 2b revealed the maximum antimicrobial potency against two bacterial strains, Staphylococcus aureus (25.