Flap size as a confounding variable in flap perfusion measurement with the Oxygen-to-see (O2C) analysis system in microvascular head and neck reconstruction - a retrospective analysis.

Objectives: The Oxygen-to-see (O2C) analysis system is used for flap monitoring based on predefined threshold values for flap perfusion. However, flap size may be a confounding variable. The aim of this study was to investigate the relationship between flap size and flap perfusion in microvascular head and neck reconstruction.

Laser doppler flowmetry as a diagnostic tool to detect gingival inflammation: a systematic review.

Background: The aim of this systematic review was to evaluate whether laser Doppler flowmetry (LDF) as a diagnostic tool is effective in detecting gingival inflammation.

Methods: This review was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and registered at the International Prospective Register of Systematic Reviews (PROSPERO) (registration number CRD42025633576). Two authors independently performed searches in PubMed, Embase, the Cochrane Library, and Scopus.

Effect of platelet-rich fibrin on microperfusion during early socket healing: a randomized controlled clinical trial.

Objectives: This study aimed to evaluate and compare the early healing of fresh alveolar sockets treated with or without platelet-rich fibrin (PRF) using laser Doppler flowmetry and tissue spectrophotometry (LDF-TS). The primary outcome was gingival perfusion; secondary outcomes included clinical wound healing (based on the Landry Wound Healing Index) and patient-reported postoperative pain.

Materials And Methods: Sixty-two patients requiring single tooth extraction were randomized into two groups.

A prospective observational study regarding host-derived immunological parameters around zirconia implants in comparison to natural teeth following flap surgery.

With the increasing use of dental implants in patients undergoing extensive mandibular reconstructions, it is crucial to understand how soft tissues react in different implantation contexts. The aim was to compare the behavior of the soft tissues surrounding zirconia implants to that of the soft tissues surrounding natural teeth in terms of cytokine levels in patients who had undergone various microvascular flap procedures for jaw reconstruction. Due to anatomical deviations after flap surgery, such as thick skin paddles, the possibility of fixed implant dentures in patients with bony flaps is rare.

Impact of Vasopressors on Microvascular Free Flap Perfusion in Head and Neck Reconstruction.

Introduction: The use of vasopressors in microvascular head and neck reconstruction is still controversial in view of its potentially negative influence on microvascular flap perfusion, which is crucial for flap viability and commonly used as a parameter in flap monitoring. The aim of this study was to investigate the influence of vasopressors on microvascular free flap perfusion.

Materials And Methods: Perfusion measurement data recorded intraoperatively and postoperatively using the Oxygen-2-see (O2C) analysis system in 274 patients undergoing microvascular head and neck reconstruction with fasciocutaneous free flaps (FFFs) or perforator free flaps (PFFs) between 2011 and 2020 were analyzed retrospectively.

Comparison of the accuracy of different slot properties of 3D-printed cutting guides for raising free fibular flaps using saw or piezoelectric instruments: an in vitro study.

Purpose: The free fibular flap (FFF) is a standard procedure for the oral rehabilitation of segmental bone defects in the mandible caused by diseases such as malignant processes, osteonecrosis, or trauma. Digital guides and computer-assisted surgery (CAS) can improve precision and reduce the time and cost of surgery. This study evaluates how different designs of slot cutting guides, guiding heights, and cutting instruments affect surgical accuracy during mandibular reconstruction.

Predictive modelling of mandibular osteoradionecrosis in head and neck cancer patients: clinical and dosimetric insights.

Introduction: Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) for head and neck cancer (HNC), with an incidence of 3-15%. ORN results from radiation-induced bone necrosis and may require surgical intervention. This study investigates clinical and dosimetric predictors of ORN risk and develops a predictive model for individualized risk assessment.

Blood pressure and microvascular free flap perfusion in head and neck reconstruction- a retrospective analysis.

Purpose: The influence of blood pressure on microvascular free flap perfusion is not fully understood and remains an ongoing topic of debate, as flap perfusion is both a prerequisite for flap viability and a parameter frequently used for postoperative flap monitoring. The aim of this study was to investigate the influence of blood pressure on microvascular free flap perfusion.

Methods: Perfusion measurement data obtained with the Oxygen-2-see (O2C) analysis system intraoperatively and postoperatively in 244 patients who underwent microvascular reconstruction of the head and neck region with a fasciocutaneous free flap (FFF) or perforator free flap (PFF) between 2011 and 2020 were analyzed retrospectively.

Continuous Measurement of Radial Free Forearm Flap Tissue Perfusion for Flap Monitoring After Microvascular Head and Neck Reconstruction-Systemic Blood Pressure as a Potential Confounder in the Early Postoperative Period.

Continuous measurement of flap tissue perfusion in the context of postoperative flap monitoring after microvascular head and neck reconstruction may be confounded by alterations in systemic blood pressure, particularly when using predefined absolute thresholds for the detection of vascular flap compromise. This study aimed to investigate the relationship between radial free forearm flap (RFFF) tissue perfusion and systemic blood pressure following head and neck reconstruction. The study included 14 patients reconstructed with an RFFF in the head and neck region between 2020 and 2022.

Confounding effects of blood hemoglobin and hematocrit levels on flap perfusion measurement with the Oxygen-to-see (O2C) analysis system in microvascular head and neck reconstruction- a retrospective study.

Background: The Oxygen-2-see (O2C) analysis system can measure flap perfusion, which is a prerequisite for flap viability, and it is therefore commonly used in flap monitoring for microvascular head and neck reconstruction. However, in the context of predefined threshold values for perfusion parameters indicating vascular flap compromise, it is unclear whether blood hemoglobin and hematocrit levels are confounding variables. The aim of this study was to investigate the influence of blood hemoglobin and hematocrit levels on flap perfusion parameters.

Hemostasis and Gingival Healing-Polyurethane Adhesive Postextraction Under Rivaroxaban Therapy in a Rodent Model.

At 31%, the risk of postoperative bleeding after tooth extraction is particularly high in patients who receive rivaroxaban therapy. The aim of this rodent study was to compare the hemostyptic properties and gingival healing between novel polyurethane-based adhesive VIVO and gelatin sponge (GESP) under ongoing rivaroxaban therapy over a period of 10 days. In total, 120 extractions of the first upper molar were proceeded in rodents treated with rivaroxaban.

An evaluation of speech therapy care in the surrounding area of an interdisciplinary cleft lip and palate tertiary care center.

The anatomical deformation in cleft patients requires speech therapy to support cleft patients as best as possible. The aim of this study was to evaluate the standard of knowledge of therapists concerning clefts. Furthermore, the study aimed to determine whether there was a difference between therapists with and without treatment experience in cleft patients as well as among therapists with more or less years of general professional experience.

Peri-Implant Health and Perfusion Parameters in Patients After Microvascular Jaw Reconstruction: A Clinical Cohort Study.

Introduction: The aim of this study was to evaluate perfusion parameters and clinical features of healthy implants and implants affected by peri-implant disease in patients who had undergone microvascular jaw reconstruction.

Methods: A total of 25 patients with 92 implants placed in microvascular transplants were included. Of these, 68 implants showed healthy peri-implant tissue, 12 were affected by peri-implant mucositis, and 12 were diagnosed with peri-implantitis.

Impact of segment length on bony changes following microvascular jaw reconstruction using virtually planned fibula flaps - A retrospective study.

Postoperative bone resorption within the first year after a free fibular flap is a common problem and poses major challenges for subsequent therapies. Due to the concerns of increased bone resorption, short segments in particular, i.e.

Determination of adequate bony resection margins in inflammatory jaw pathologies using SPECT-CT in primary mandibular reconstruction with virtually planned vascularized bone flaps.

Objectives: In advanced stages of osteoradionecrosis, medication-related osteonecrosis of the jaw, and osteomyelitis, a resection of sections of the mandible may be unavoidable. The determination of adequate bony resection margins is a fundamental problem because bony resection margins cannot be secured intraoperatively. Single-photon emission computed tomography (SPECT-CT) is more accurate than conventional imaging techniques in detecting inflammatory jaw pathologies.

Multi-label segmentation of carpal bones in MRI using expansion transfer learning.

The purpose of this study was to develop a robust deep learning approach trained with a smallMRI dataset for multi-label segmentation of all eight carpal bones for therapy planning and wrist dynamic analysis.A small dataset of 15 3.0-T MRI scans from five health subjects was employed within this study.

Segmentation of the iliac crest from CT-data for virtual surgical planning of facial reconstruction surgery using deep learning.

Background And Objectives: For the planning of surgical procedures involving the bony reconstruction of the mandible, the autologous iliac crest graft, along with the fibula graft, has become established as a preferred donor region. While computer-assisted planning methods are increasingly gaining importance, the necessary preparation of geometric data based on CT imaging remains largely a manual process. The aim of this work was to develop and test a method for the automated segmentation of the iliac crest for subsequent reconstruction planning.

Evaluation of zirconia implants in fibula and deep circumflex iliac artery flaps: a prospective 1.5-year follow-up study.

Objectives: Follow-up results of modern zirconia implants inserted in fibula free and deep circumflex iliac artery (DCIA) flaps with fixed dentures are scarce. This study aimed to evaluate crestal bone changes and the survival rate of zirconia implants for up to 1.5 years of prospective follow-up.

Influence of antiplatelet medication and anticoagulation therapy after dental extractions on hospitalization: a retrospective 10-year study.

Background: The aim of this retrospective study was to identify high-risk dental extraction patients and the timing of postoperative hemorrhage to evaluate whether preventive hospitalization should be considered in patients on antiplatelet medication (AP) or anticoagulants.

Methods: Our study included 1595 procedures; 1319 were conducted under monotherapy (Group I: AP; Group II: indirect oral anticoagulant [IAC]; Group III: direct oral anticoagulant [DOAC]) and 276 under dual therapy (Group IV: double AP; Group V: AP and IAC; Group VI: AP and DOAC). We evaluated the incidence, frequency and timing of hemorrhage, hospitalization rate, and treatment of bleeding incidents.

Assessing the Influence of Hyaluronan Dressing on Wound Healing on Split-Thickness Skin Graft Donor Sites Using a Three-Dimensional Scanner.

The topical application of hyaluronic acid after injury may accelerate the wound healing process. We aimed to retrospectively investigate whether the topical application of hyaluronic acid on standardized wounds after split-thickness skin graft removal on the thigh would accelerate wound healing and improve scarring outcomes. Additionally, we aimed to evaluate the usefulness of three-dimensional (3D) scanning to assess scars.

Evaluation of the use of an advanced platelet-rich fibrin (A-PRF+) membrane in children undergoing primary palatoplasty-- a prospective randomized clinical pilot-study.

The aim of this study was to evaluate whether an A-PRF + membrane can lower the fistula rate in patients undergoing primary palatoplasty. A total of 20 children were included: 10 were randomized and included in the platelet-rich fibrin (PRF) group, and 10 were assigned to the control group. Before two-flap palatoplasty was performed, the cleft's width was measured.

Measuring the esthetic outcome using a three-dimensional facial scanner after parotidectomy and application of vascularized fat flaps.

Background: Parotidectomy can affect facial symmetry. Our study evaluated the symmetry of different facial areas and upper neck after total parotidectomy and filling the area with vascularized fat flap (VFF).

Methods: Facial symmetry was evaluated in eight patients and a control group matched in terms of gender and age, using a three-dimensional (3D) facial scanner.