The effect of physical interventions in older adults on inflammatory markers (IL-6, IL-10, CRP, TNF-α): an umbrella review of systematic reviews and meta-analyses.

Background And Objectives: The occurrence of chronic low-grade inflammation during aging, also referred to as "," can impair immunological homeostasis and threaten healthy ageing. Different physical exercise interventions have been proposed to tackle inflammageing. The aim of this umbrella review was to appraise current evidence from systematic reviews, with or without meta-analyses, on the effect of exercise interventions on circulating levels of inflammatory markers C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and the anti-inflammatory marker interleukin 10 (IL-10) in community-dwelling older adults.

Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank.

Frailty is a geriatric multidimensional syndrome characterized by a loss of physiologic reserves and disproportionate vulnerability to external stressors and associated with increased risk of multiple negative health outcomes. Since frailty can be prevented, controlled, and even reverted in its early stages, identifying the main factors involved in its development is crucial to implement preventive and/or restorative interventions. The aim of this study was to assess the impact of a broad range of parameters, including host factors, lifestyle, diet, and environmental and occupational conditions, on the development of frailty in later life.

Association between cognitive reserve proxies and frailty phenotype: data from UK Biobank.

A potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank.

Animal injury characteristics following the 2020 ammonium nitrate explosion in the Port of Beirut.

Purpose: To describe the characteristics and veterinary management of animal casualties after an ammonium nitrate explosion in the Port of Beirut.

Methods: Retrospective evaluation of medical records from multiple veterinary organizations.

Results: Veterinary care was administered to 298 cats and 103 dogs, with 101 animals (25%) undergoing surgical procedures under general anesthesia.