Publications by authors named "Alexandra Gotthardt"
Phthalates are widely used in consumer products and are well-known for adverse endocrine outcomes. Di-(2-ethylhexyl) phthalate (DEHP), one of the most extensively used phthalates, has been rapidly substituted with alternative plasticizers in many consumer products. The aim of this study was to assess urinary phthalate and alternative plasticizer exposure and associated risks in children of three Asian countries with different geographical, climate, and cultural characteristics.
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- Diisononyl adipate (DINA) is a plasticizer used in PVC products, serving as an alternative to restricted phthalates, and the study investigates its metabolism and excretion in humans.
- The research identified three specific DINA metabolites — OH-MINA, oxo-MINA, and cx-MIOA — and measured their urinary excretion after administering a single oral dose to healthy individuals.
- The findings revealed that OH-MINA was the predominant metabolite, but overall urinary excretion of these metabolites was low, suggesting that most of the DINA dose is eliminated as non-specific metabolites, with no detectable levels found in a pilot population with no known DINA exposure.
Article Synopsis
- Di-n-butyl adipate (DnBA) serves as a plasticizer and an alternative to the endocrine disruptor di-n-butyl phthalate, being used in various consumer products, including personal care items.
- A study involving three volunteers measured how DnBA is metabolized and excreted post oral and dermal dosage, analyzing urine samples for specific metabolites over a set period.
- The findings indicated that certain metabolites, especially mono-n-butyl adipate and 3-hydroxy-mono-n-butyl adipate, could serve as reliable exposure biomarkers for DnBA, though overall metabolite excretion was low and consistent across participants.