Publications by authors named "Alexandra Condado de Abreu"
Proc Natl Acad Sci U S A
April 2021
Article Synopsis
- Vascular calcification is linked to the risk of atherosclerotic plaque rupture and cardiovascular events, and while bisphosphonates (BiPs) may help, they have mixed effects on patient outcomes.
- In laboratory and animal models, BiPs like ibandronate were shown to influence the size and shape of microcalcifications that could affect plaque stability by reducing stress on the fibrous cap.
- The study confirmed the effectiveness of a 3D hydrogel system for investigating how extracellular vesicles contribute to mineral formation in vascular calcification and testing potential treatments.
