The Circulating Lipidome In Severe Obesity.

Background: Severe obesity (SevO; BMI ≥40 kg/m) is rapidly increasing globally and disproportionately affects minority populations. However, it remains understudied in mechanistic and omics literature. Lipid metabolism plays a central role in obesity-related cardiometabolic disease (CMD), but the relationship between molecular lipid species and SevO is poorly understood, particularly in high-risk groups.