Publications by authors named "Alexandra B Kinzer"
Background: Despite the known impact of social deprivation on kidney transplant access, no instrument exists that quantifies the likelihood of receiving a transplant using neighborhood-level socioeconomic deprivation.
Methods: Patients referred for kidney transplant evaluation from July 2017 and January 2022 were evaluated. Patients' addresses were geocoded using the DeGAUSS (Decentralized Geomarker Assessment for Multi-Site Studies) system, and deprivation index was generated.
Article Synopsis
- The study assesses the long-term survival and outcomes of liver transplant patients who required temporary abdominal closure versus those who had primary fascial closure, using data from 2013 to 2017 with a 5-year follow-up.
- Among 436 liver transplants, 17.2% needed temporary closure, which was associated with higher preoperative sickness (like higher MELD scores and more dialysis), and these patients also experienced longer hospital stays and higher readmission rates within 30 days.
- While initial 1-year survival rates were lower for those with temporary closure (82.7% vs 90.9%), 5-year survival rates were not significantly different, indicating that temporary closure is a safe alternative with comparable long-term
Context: Insulin resistance (IR) is associated with polycystic ovaries and hyperandrogenism, but underpinning mechanisms are poorly understood and therapeutic options are limited.
Objective: To characterize hyperandrogenemia and ovarian pathology in primary severe IR (SIR), using IR of defined molecular etiology to interrogate disease mechanism. To extend evaluation of gonadotropin-releasing hormone (GnRH) analogue therapy in SIR.
Context: Patients with lipodystrophy have dyslipidemia and insulin resistance. Leptin treatment with metreleptin in lipodystrophy decreases insulin resistance and lowers triglycerides without changing high-density lipoprotein. Detailed measurement of lipoprotein particles with nuclear magnetic resonance (NMR) spectroscopy can offer insights into cardiovascular disease (CVD) risk and lipid metabolism beyond a standard lipid panel.
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