Predicting risk of cardiovascular events (PREVENT) score accuracy among people with HIV in the multicenter CNICS cohort.

Background: People with HIV (PWH) are at elevated cardiovascular risk, but existing calculators have suboptimal calibration for this population. The American Heart Association developed new prediction equations (PREVENT) to replace the pooled cohort equations (PCE). PREVENT has not been validated among PWH.

Multicenter study of heart failure phenotypes and physician-adjudicated causes in people with HIV.

Background: Limited systematic data exist on heart failure phenotypes in contemporary HIV care, and no prior multicenter studies have investigated physician-adjudicated phenotypes and causes of heart failure in people with HIV (PWH).

Methods: We adjudicated heart failure events and sub-phenotypes occurring between January 1, 2010, and December 31, 2021, at two large urban clinical centers within the CFAR Network of Integrated Clinical Systems (CNICS) cohort. Using Cox proportional hazard regression, hazard ratios were calculated to examine associations of HIV-specific and cardiometabolic risk factors with incident heart failure among PWH.

Glycated Hemoglobin as an Integrator of Cardiovascular Risk in Individuals Without Diabetes: Lessons from Recent Epidemiologic Studies.

Purpose Of Review: Prediabetes, or dysglycemia in the absence of diabetes, is a prevalent condition typically defined by a glycated hemoglobin (HgbA1c) of 5.7- < 6.5%.

Management of Severe and Moderate Hypercholesterolemia in Young Women and Men.

This study uses clinical registry data to assess achievement of low-density lipoprotein cholesterol reduction and lipid-lowering therapy prescribing patterns among adults aged 20 to 39 years with moderate to severe hypercholesterolemia.