Statistical Molecular Interaction Fields: A Fast and Informative Tool for Characterizing RNA and Protein-Binding Pockets.

Developing a physical understanding of the interactions between a macromolecular target and its ligands is a crucial step in structure-based drug design. Although many tools exist to characterize protein-binding pockets in silico, this is not yet the case for RNA, which has been recognized only recently as a suitable target for small ligands. Molecular Interaction Fields (MIFs) are useful tools to characterize the interactions of a given binding pocket.