Gradient Insulator-Based Dielectrophoresis of Gold Nanoparticles.

Various forms of dielectrophoresis and higher order electrokinetic effects are being increasingly investigated and used to precisely and accurately manipulate micro and nanoparticles within microfluidic devices. The types of particles span ∼10 nm to hundreds of microns in diameter and are composed of minerals, polymers, biological materials, and complex mixtures. Some studies focused on the selective isolation and concentration of purified particles countering negative dielectrophoretic forces against flow and electrophoretic effects.

Implementation of A New, Mobile Diabetic Retinopathy Screening Model Incorporating Artificial Intelligence in Remote Western Australia.

Objective: Diabetic retinopathy (DR) screening rates are poor in remote Western Australia where communities rely on outdated primary care-based retinal cameras. Deep learning systems (DLS) may improve access to screening, however, require validation in real-world settings. This study describes and evaluates the implementation of a new, mobile DR screening model that incorporates artificial intelligence (AI) into routine care.

Disparities in Telehealth use During the COVID-19 Pandemic.

The coronavirus 2019 pandemic led to rapid expansion of outpatient telemedicine. We sought to characterize patient factors influencing outpatient teleneurology utilization at an urban safety-net hospital. We reviewed all neurology televisits scheduled between June 15, 2020 to April 15, 2021.

Understanding the #longCOVID and #longhaulers Conversation on Twitter: Multimethod Study.

Background: The scientific community is just beginning to uncover the potential long-term effects of COVID-19, and one way to start gathering information is by examining the present discourse on the topic. The conversation about long COVID-19 on Twitter provides insight into related public perception and personal experiences.

Objective: The aim of this study was to investigate the #longCOVID and #longhaulers conversations on Twitter by examining the combined effects of topic discussion and social network analysis for discovery on long COVID-19.

Associations of physical activity with gut microbiota in pre-adolescent children.

Purpose: To determine whether physical activity (PA), primarily the recommended 60 minutes of moderate-to-vigorous PA, is associated with gut bacterial microbiota in 10-year-old children.

Methods: The Block Physical Activity Screener, which provides minutes/day PA variables, was used to determine whether the child met the PA recommendations. 16S rRNA sequencing was performed on stool samples from the children to profile the composition of their gut bacterial microbiota.

A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia.

Objectives: RNASEH1 gene has recently been associated with type 1 diabetes (T1D) in Colombia. The purpose of this study was to fine mapping the putative functional variant in RNASEH1 and testing its interaction with HLA tagSNPs.

Methods: Two-hundred nuclear families with T1D were included in this study.

Epitope Presentation of Dengue Viral Envelope Glycoprotein Domain III on Hepatitis B Core Protein Virus-Like Particles Produced in .

Dengue fever is currently ranked as the top emerging tropical disease, driven by increased global travel, urbanization, and poor hygiene conditions as well as global warming effects which facilitate the spread of mosquitoes beyond their current distribution. Today, more than 100 countries are affected most of which are tropical Asian and Latin American nations with limited access to medical care. Hence, the development of a dengue vaccine that is dually cost-effective and able to confer a comprehensive protection is ultimately needed.

Surface contamination in the operating room: use of adenosine triphosphate monitoring.

Purpose: We prospectively investigated contamination of high-contact surfaces in the operating room (OR) using adenosine triphosphate (ATP) monitoring. We tested whether contamination would increase from morning (AM) to afternoon (PM), despite cleaning between cases. Second, we compared the degree of OR contamination to non-OR control sites.

Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates.

Background: The lack of a universal influenza vaccine is a global health problem. Interest is now focused on structurally conserved protein domains capable of eliciting protection against a broad range of influenza virus strains. The long alpha helix (LAH) is an attractive vaccine component since it is one of the most conserved influenza hemagglutinin (HA) stalk regions.

Epidemiological characterization of diabetic patients on therapy with continuous subcutaneous insulin infusion and continuous glucose monitoring in real time.

Objective: To describe baseline characteristics of diabetic patients who were started on insulin pump and real time continuous glucose monitor (CSII-rtCGM) in a specialized center in Medellin, Colombia.

Materials And Methods: All patients with diabetes with complete data who were started on CSII-rtCGM between February 2010 and May 2014 were included. This is a descriptive analysis of the sociodemographic and clinical characteristics.

Progress in the Diagnosis and Classification of Pituitary Adenomas.

Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are difficult to treat due to their tendency to recur despite standardized treatment.

ReLA, a local alignment search tool for the identification of distal and proximal gene regulatory regions and their conserved transcription factor binding sites.

Motivation: The prediction and annotation of the genomic regions involved in gene expression has been largely explored. Most of the energy has been devoted to the development of approaches that detect transcription start sites, leaving the identification of regulatory regions and their functional transcription factor binding sites (TFBSs) largely unexplored and with important quantitative and qualitative methodological gaps.

Results: We have developed ReLA (for REgulatory region Local Alignment tool), a unique tool optimized with the Smith-Waterman algorithm that allows local searches of conserved TFBS clusters and the detection of regulatory regions proximal to genes and enhancer regions.

Helical prospective ECG-gating in cardiac computed tomography: radiation dose and image quality.

Helical prospective ECG-gating (pECG) may reduce radiation dose while maintaining the advantages of helical image acquisition for coronary computed tomography angiography (CCTA). Aim of this study was to evaluate helical pECG-gating in CCTA in regards to radiation dose and image quality. 86 patients undergoing 64-multislice CCTA were enrolled.

Identification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccidioidomycosis and adrenal insufficiency.

The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that of the adrenal insufficiency in the second patient.

Validating a knowledge transfer framework in health services.

The study of knowledge transfer (KT) has been proceeding in parallel but independently in health services and in business, presenting an opportunity for synergy and sharing. This paper uses a survey of 32 empirical KT studies with their 96 uniquely named determinants of KT success to identify ten unique determinants for horizontal knowledge transfer success. These determinants, the outcome measure of Knowledge Use, and separate explicit and tacit transfer flows constitute the KT Framework, extending the work of previous KT framework authors.

Factors regulating gastric emptying in preterm infants.

Objectives: To determine whether osmolality, volume, or energy density affects gastric emptying rate (GE); whether simultaneously decreasing osmolality and increasing volume accelerates GE; and whether GE is related to any clinical and/or demographic characteristics.

Study Design: GE was measured using the (13)C-octanoic acid breath test in 17 infants of 25 to 30 weeks gestation in a tertiary care children's hospital. In study 1, the independent effects of osmolality, volume, and nutrient density were evaluated in 10 infants.