Starch Biopolymer Functionalized with Ipomoea batatas Extract: A Natural System for Bioactive Delivery in Type II Diabetes.

Introduction: Type 2 diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. Natural compounds derived from plants, such as Ipomoea batatas, have shown therapeutic potential for its treatment.

Methods: A starch-based biopolymer was developed and functionalized with a methanolic extract of Ipomoea batatas (IBM).

Optimization of ultrasonic-assisted extraction of polyphenols from the polyherbal formulation of , and and their anti-diabetic capacity in zebrafish ().

The , and (OV) have been used in traditional medicine in several regions of México for their anti-diabetic properties. In this study investigated the variables of ultrasound-assisted extraction for the polyphenolic compounds from the combination of these plants and explore their potential antidiabetic activities on glucose-induced-diabetic zebrafish. Determined the optimum conditions for ultrasonic-assisted extraction (UAE) to maximum recovery amounts of phenolic compounds from the extract of these plants.

Evaluation of the Antidiabetic Potential of Extracts of , , and in Mice, Zebrafish, and Pancreatic β-Cell.

Medicinal plants are commonly used in the treatment of diabetes, particularly as they contain flavonoids and phenolic compounds. The present study aims to investigate the activities of a polyherbal formulation made from , , and (UAZ) against streptozotocin-nicotinamide ((STZ-NA)-induced type 2 diabetes in CD1 mice, glucose-induced type 2 diabetes (T2DM) in zebrafish, and high glucose-induced damage in RINm5F pancreatic β-cells. In fasting mice, plasma glucose, glycosylated hemoglobin (HbA1C), lipid hydroperoxides (LOOH), thiobarbituric acid reactive substances (TBARS), and lipid profiles were significantly increased, whereas insulin, enzymatic antioxidants, and carbohydrate metabolic enzymes were altered significantly in diabetic mice.

Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Seeds in a Diabetic Zebrafish Model.

Diabetes mellitus (DM) is a serious chronic degenerative disease characterized by high levels of glucose in the blood. It is associated with an absolute or relative deficiency in the production and/or action of insulin. Some of the complications associated with DM are heart disease, retinopathy, kidney disease, and neuropathy; therefore, new natural alternatives are being sought to control the disease.

Phytochemical and Pharmacological Study of the Genus.

The participation of natural products in health care has been remarkable, and today they continue to play a key role in the discovery and development of new treatments. Phytochemical studies together with pharmacological tests have managed to integrate bioactive agents as an alternative solution to reduce or regulate the problems caused by diseases. The genus is a family of plants that are rich in secondary metabolites, which have shown potential activity in the control and mitigation of urinary disorders, diabetes, oxidative stress, protein glycosylation, microbial infections, inflammation, pain or discomfort, muscle contractions, cytotoxicity, or as a cellular or neuronal signaling modulator.

A Review of the genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties.

is one of the largest genera of the Ephedraceae family, which is distributed in arid and semiarid regions of the world. In the traditional medicine from several countries some species from the genus are commonly used to treat asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. The chemical constituents of species have been of research interest for decades due to their contents of ephedrine-type alkaloids and its pharmacological properties.

Antidiabetic Activity of Leaves.

This research evaluated the potential of using the methanol extract of (L.) Burm.f (AVM) to prevent the formation of AGEs by means of the BSA/glucose assay, BSA-methylglyoxal assay, arginine-methylglyoxal assay, fructosamine, N-(carboxymethyl) lysine (CML), thiol groups, and carbonyl protein .

3'--β-d-glucopyranosyl-α,4,2',4',6'-pentahydroxy-dihydrochalcone, from Bark of Prevents Diabetic Nephropathy via Inhibiting Protein Glycation in STZ-Nicotinamide Induced Diabetic Mice.

Previous studies have shown that accumulation of advanced glycation end products (AGEs) can be the cause of diabetic nephropathy (DN) in diabetic patients. Dihydrochalcone 3'--β-d-glucopyranosyl α,4,2',4',6'-pentahydroxy⁻dihydrochalcone () is a powerful antiglycation compound previously isolated from . The aim was to investigate whether () was able to protect against diabetic nephropathy in streptozotocin (STZ)-induced diabetic mice, which displayed renal dysfunction markers such as body weight, creatinine, uric acid, serum urea, total urinary protein, and urea nitrogen in the blood (BUN).

Protection of silver nanoparticles using in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish.

Background: The aim was to explore the efficacy of extract of -loaded silver nanoparticles (EP/AgNPs) on pancreatic β cells, INS-1 cells, and zebrafish as a valuable model for the study of diabetes mellitus.

Materials And Methods: EP/AgNPs were synthesized using methanol/water bark extract of and characterized using various physicochemical techniques.

Results: Immersion of adult zebrafish in 111 mM glucose solution resulted in a sustained hyperglycemic, hyperlipidemic state, and serum insulin levels decreased.

Properties of Flavonoids Isolated from the Bark of and Their Effect on Oxidative Stress in Streptozotocin-Induced Diabetes Mellitus in Mice.

Six new flavonoids 2',4'-dihydroxychalcone-6'-O--d-glucopyranoside (), ,3,2',4'-tetrahydroxy-4-methoxy-dihydrochalcone-3'-C--glucopyranosy-6'-O--d-glucopyranoside (), 7-hydroxy-5,8'-dimethoxy-6'-l-rhamnopyranosyl-8-(3-phenyl-trans-acryloyl)-1-benzopyran-2-one (), 6'7-dihydroxy-5,8-dimethoxy-8(3-phenyl-trans-acryloyl)-1-benzopyran-2-one (), 9-hydroxy-3,8-dimethoxy-4-prenylpterocarpan (), and ,4,4'-trihydroxydihydrochalcone-2'-O--d-glucopyranoside () were isolated from bark of Antidiabetic activity of compounds - in terms of their cellular antioxidant and free radical scavenging and also in streptozotocin- (STZ-) induced diabetic mice was evaluated on liver transaminases, lipid peroxidation, total bilirubin, total protein, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (CSH-Px), and glutathione reductase (GSH). Results indicated that - scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (OH), nitric oxide radicals (NO), superoxide anion radical (O), radical cation (ABTS), and hydrogen peroxide (HO) radical, and protection against HO induced BSA damage was also observed. Furthermore, - showed ability to decrease the oxidative stress in H9c2 cell.

Hypoglycemic Effects of sesquiterpene lactones from .

The novel dimeric guaianolides sesquiterpene lactone Byrsoninas A and B from seed hexane extract of were identified. Streptozotocin-induced mildly diabetic and severely diabetic mice were treated with these oral administrations at a dosage of 20 mg/kg of body weight per day for 30 days. Also the protective effect in RIN-5F cells against oxidative stress was investigated and TNF-α and IL-6 levels were measured.

Hexane extract of the seeds of Byrsonima crassifolia accelerates wound healing in streptozotocin-induced diabetic rats.

Objetive: To study the effect of seeds of Byrsonima crassifolia in diabetic wound healing.

Methods: Wound healing potential of hexane extract in the form of simple ointment for the treatment of dermal wounds was studied in streptozotocin-induced diabetic rats on excision wound, incision wound and dead space wound. Various parameters such as epithelization period, scar area, tensile strength, hydroxyproline, total protein, DNA, hexosamine, uronic acid, antioxidant enzymes including superoxide dismutase (SOD) and catalase activity (CAT) were used to evaluate the effect of B.

Anti-inflammatory activity of the hexane extract of Byrsonima crassifolia seeds in experimental animal models.

Context: Byrsonima crassifolia is a tropical tree, commonly known as nance and distributed widely in Mexico and Central and South America. Since pre- Hispanic times, the seeds of the fruits have been used in folklore medicine as an anti-inflammatory; however, currently no researchers have examined its potential pharmacological properties in scientific studies.

Objective: This study investigated the anti-inflammatory activity of extracts obtained with the solvents n-hexane, chloroform, and methanol from seeds of B crassifolia.

Antihyperglycemic, antihyperlipidemic and antiglycation effects of Byrsonima crassifolia fruit and seed in normal and streptozotocin-induced diabetic rats.

The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and oxidized glutathione (GSSG) levels. The most active extracts were obtained with hexane.