Predicting Retinal Nerve Fiber Layer Thickness From Ocular Hypertension Treatment Study Optic Disc Photographs.

Importance: Deep learning predictions of retinal nerve fiber layer (RNFL) thickness derived from optic disc photographs may help to determine risk for development of primary open-angle glaucoma (POAG) in patients with ocular hypertension.

Objective: To predict mean RNFL thickness from the optic disc photographs from the Ocular Hypertension Treatment Study (OHTS) and assess the utility of predicted RNFL thickness as a risk factor for the development of POAG.

Design, Setting, And Participants: This diagnostic study evaluated 3272 eyes from 1636 participants with ocular hypertension but without POAG at the time of enrollment in the OHTS 1 and 2 trials.

Repeatability of Fractal Analysis in OCT Angiography of the Macula and Optic Nerve Head.

Purpose: To evaluate the repeatability of OCT angiography (OCTA) vessel density measurements using fractal analysis in the macula and optic nerve head (ONH) regions.

Design: A prospective longitudinal observational cohort study.

Participants: One hundred sixteen eyes from 71 primary open-angle glaucoma patients with valid macula OCTA scans and 91 eyes from 59 primary open-angle glaucoma patients with valid ONH OCTA scans, with 53 patients contributing scans for both regions.

Intraocular Pressure Measurements With the Tono-Vera: A New Handheld Rebound Tonometer.

Prcis: In a cross-sectional study comparing the novel Tono-Vera handheld rebound tonometer with the Ocular Response Analyzer, a strong agreement was found between the intraocular pressure measurements of the 2 devices.

Purpose: To compare intraocular pressure (IOP) measurements obtained by the new Tono-Vera (Reichert Technologies), a novel handheld rebound tonometer with a proprietary camera-based positioning system, with those from the Ocular Response Analyzer (ORA, Reichert Technologies) non-contact tonometer.

Patients: Fifty-four eyes of normal individuals and open angle glaucoma subjects.

Effect of Blood Pressure on Rates of Progression in Focal Ischemic vs. Generalized Cup Enlargement Glaucoma Phenotypes.

Purpose: To investigate the impact of blood pressure (BP) on rates of retinal nerve fiber layer (RNFL) thinning in glaucomatous eyes with focal ischemic (FI) vs. generalized cup enlargement (GE) optic disc phenotypes.

Design: Prospective cohort study.

Impact of race and ethnicity on glaucoma progression detection by perimetry and optical coherence tomography.

This study assessed the impact of race and ethnicity on longitudinal test variability and time to detect glaucoma progression using standard automated perimetry (SAP) and optical coherence tomography (OCT). The sample consisted of 47,003 SAP tests from 5402 eyes and 25,480 OCT tests from 4125 eyes, with 20% of participants self-identifying as Black or African American and 80% as White; 29% as Hispanic or Latino and 71% as Not Hispanic or Latino. Variability was measured using standard deviations of residuals from linear regression models for SAP mean deviation (MD) and OCT retinal nerve fiber layer (RNFL) thickness over time.

Accelerated Epigenetic Aging Is Associated with Faster Glaucoma Progression: A DNA Methylation Study.

Purpose: To investigate the association between epigenetic age acceleration and glaucoma progression.

Design: Retrospective cohort study.

Participants: A total of 100 patients with primary open-angle glaucoma (POAG) with fast progression and 100 patients with POAG with slow progression.

Estimated Rates of Retinal Ganglion Cell Loss with Aging.

Purpose: To evaluate the effect of aging on estimated retinal ganglion cell (RGC) counts over time in healthy eyes, obtained from a combination of structural and functional information.

Design: Longitudinal observational cohort study.

Participants: One hundred healthy eyes of 50 subjects.

Finger-controlled nonultrasonic lens extractor.

Purpose: To report initial surgical experience and learning curve with a new finger-controlled, ultrasoundless lens extractor device and provide insights for future surgical endeavors.

Setting: Bascom Palmer Eye Institute, Miami, Florida.

Design: Single-center, noncomparative, retrospective, consecutive case series.

Relationship between Blood Pressure and Rates of Glaucomatous Visual Field Progression: The Vascular Imaging in Glaucoma Study.

Purpose: To examine the relationship between systemic arterial blood pressure (BP) and the rate of change in standard automated perimetry (SAP) in eyes with glaucoma and suspected glaucoma.

Design: Prospective cohort study.

Participants: One hundred twenty-four eyes (91 eyes with glaucoma, 33 eyes with suspected glaucoma) of 64 patients (mean age, 68.

Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma.

Background/aims: Although obesity, tobacco and alcohol consumption were linked to the progression of numerous chronic diseases, an association of these social history aspects with glaucoma progression is not yet determined. This study aims to investigate the effect of body mass index (BMI) and history of tobacco and alcohol use on the rates of retinal nerve fibre layer (RNFL) change over time in glaucoma patients.

Methods: 2839 eyes of 1584 patients with glaucoma from the Duke Ophthalmic Registry were included.

Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.

Purpose: To describe visual field outcomes in the Primary Tube Versus Trabeculectomy (PTVT) Study.

Design: Cohort analysis.

Participants: A total of 155 eyes (155 subjects) randomly assigned to treatment with tube shunt surgery (n = 84) or trabeculectomy with mitomycin C (n = 71).

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Purpose: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months in the Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Design: Prospective cohort study.

Participants: A total of 125 eyes from 65 primary open-angle glaucoma (POAG) subjects.

Increasing Rates of Herpes Zoster Ophthalmicus and the COVID-19 Pandemic.

Purpose: This epidemiologic study evaluates the variance in incidence of Herpes Zoster (HZ) and Herpes Zoster Ophthalmicus (HZO) within a single healthcare system with an aim to analyze their relationship to the COVID-19 pandemic.

Methods: All patients attending the Duke University Health System (DUHS) from January 1, 2018, to December 31, 2021, were included. General and COVID-related trends of HZO and HZ were analyzed based on new ICD-9 or ICD-10 diagnosis codes, compared with the total number of patients seen at DUHS during this period, and the number of reported COVID-19 cases in North Carolina obtained using the CDC data tracker.

Improved Prediction of Perimetric Loss in Glaucomatous Eyes Using Latent Class Mixed Modeling.

Purpose: To evaluate whether the identification of distinct classes within a population of glaucoma patients improves estimates of future perimetric loss.

Design: Longitudinal cohort study.

Participants: A total of 6558 eyes of 3981 subjects from the Duke Ophthalmic Registry with ≥ 5 reliable standard automated perimetry (SAP) tests and ≥ 2 years of follow-up.

Hazard Detection During Simulated Driving in Glaucoma Patients.

Prcis: In this cross-sectional study, glaucoma patients showed slower reaction times (RTs) to hazardous situations when compared with control subjects during simulated driving. Worse RTs were associated with a greater magnitude of visual field loss.

Purpose: The purpose of this study was to evaluate the impact of different hazardous traffic conditions on driving performance in glaucoma patients using a high-fidelity driving simulator.

Intraocular Pressure and Rates of Macular Thinning in Glaucoma.

Purpose: To evaluate the effect of intraocular pressure (IOP) on the rates of macular thickness (ganglion cell layer [GCL] and ganglion cell-inner plexiform layer [GCIPL]) change over time measured by spectral-domain (SD) OCT.

Design: Retrospective cohort study.

Participants: Overall, 451 eyes of 256 patients with primary open-angle glaucoma.

Spectral-Domain OCT Lens Meridian Position as a Metric to Estimate Postoperative Anatomical Lens Position.

Purpose: To evaluate the prediction of postoperative anatomical lens position (ALP) using intraoperative spectral-domain optical coherence tomography (SD-OCT) lens anatomy metrics in patients who underwent femtosecond laser-assisted cataract surgery.

Methods: Intraoperative SD-OCT (Catalys; Johnson & Johnson Vision) and postoperative optical biometry (IOLMaster 700; Carl Zeiss Meditec AG) were used to assess anterior segment landmarks, including lens thickness, lens volume, anterior chamber depth, lens meridian position (LMP), and measured ALP. LMP was defined as the distance from the corneal epithelium to the lens equator, and ALP was defined as the distance from the corneal epithelium to the IOL surface.

Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.

Purpose: Glaucoma is the leading cause of irreversible blindness, a crippling disability resulting in higher risks of chronic health conditions. To better understand disparities in blindness risk, we identified risk factors of blindness on first presentation to a glaucoma clinic using a large clinical database.

Design: Retrospective cross-sectional study.

The Definition of Glaucomatous Optic Neuropathy in Artificial Intelligence Research and Clinical Applications.

Objective: Although artificial intelligence (AI) models may offer innovative and powerful ways to use the wealth of data generated by diagnostic tools, there are important challenges related to their development and validation. Most notable is the lack of a perfect reference standard for glaucomatous optic neuropathy (GON). Because AI models are trained to predict presence of glaucoma or its progression, they generally rely on a reference standard that is used to train the model and assess its validity.

Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Thickness for Diagnosing Early to Moderate Glaucoma.

Prcis: In a cross-sectional study from a Brazilian multiracial population, minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness measurements from OCT showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes.

Purpose: The purpose of this study is to compare the ability of MRW and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in discriminating early to moderate glaucoma from healthy eyes in a Brazilian population.

Methods: A total of 155 healthy controls and 118 patients with mild to moderate glaucoma (mean deviation >-12 dB) underwent MRW and RNFLT measurements with optical coherence tomography.

Rates of Visual Field Change in Eyes With Optic Disc Drusen.

Background: Optic disc drusen (ODD) are calcified deposits in the prelaminar portion of the optic nerve head. Although often asymptomatic, these deposits can cause progressive visual field defects and vision loss. The purpose of this study was to evaluate rates of functional loss in eyes with ODD and to investigate risk factors associated with rates of visual field progression.

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression.

Purpose: To investigate whether rates of standard automated perimetry (SAP) mean deviation (MD) over an initial 2-year follow-up period were predictive of events of visual field progression over an extended follow-up.

Design: Longitudinal, prospective, observational study.

Participants: Two hundred forty-six eyes of 168 patients with glaucoma followed up every 6 months for up to 5 years.