Adipocyte differentiation of 3T3-L1 cells under tenofovir alafenamide, tenofovir disoproxil fumarate, and integrase strand transfer inhibitors selective challenge: an in-vitro model.

Objective: Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral therapy (ART) medications with a good tolerability profile and a high genetic barrier to HIV drug resistance. However, several studies report significant weight gain among persons receiving INSTI-based ART regimens compared with other regimens.

Design: In-vitro model of adipogenesis.

The precautionary principle and genetically modified organisms: A bone of contention between European institutions and member states.

This manuscript examines how the Precautionary Principle has been applied to provide a mechanism for protection of the environment and health in response to the introduction of Genetically Modified Organisms (GMOs) in Europe. It discusses how the Court of Justice of the European Union (CJEU) handled national requests across four cases in which Member States had failed in their attempt to trigger the Precautionary Principle in order to uphold a ban or suspension of the cultivation or sale of GMOs in their territory. The analysis of these judgements suggests that the court has applied a narrow interpretation to the scientific evidence emerging from risk assessments, and has thereby limited the potential for precautionary measures by Member States to be upheld by the court.

Are WTO Decisionmakers Regulating Technological Risks or Are Technological Risks Steering WTO Biotechnology Legal Decisions?

This article explores how technological risks and uncertainty carried by the international trade of biotechnology are regulated under the World Trade Organization (WTO) and have been governed by the WTO's judicial bodies. The article shows that the judicial evaluation of biotechnology risks is mostly justified in scientific terms and is still anchored to a quantitative approach. This, in turn, prevents WTO decisionmakers from performing a broader analysis of the societal purposes and impacts of technological innovations and, accordingly, their potential contributions to or disadvantages for the public interest.

Chronic eosinophilic ascites in a very young child.

Unlabelled: A case of chronic eosinophilic ascites with onset in early infancy is described. An intensive diagnostic work-up ruled out other known causes of ascites in childhood. The final diagnosis was made at 2 years of age when a large number of eosinophils was detected in the ascitic fluid.