Multi-wavelength internal standardization using inductively coupled plasma optical emission spectrometry.

Background: Recent developments in trace analyte determinations can largely be described as "multi-signal" methods, in which both axes of calibration curves are measured instrumental signals instead of the traditional relationship between analyte signal and concentration. While multi-signal methods have various benefits, many are limited in sample throughput, have a limited ability to correct for matrix effects, or require each analyte species to have several significant measurable signals. Multi-wavelength internal standardization (MWIS) is a novel strategy that directly addresses the limitations of some of the recently described multi-signal techniques, using multiple emission wavelengths for both analyte species and a suite of internal standards.