Publications by authors named "Alba Urena Guzman"
Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum disorder (ASD). However, the role of a major pathway controlling protein synthesis, the integrated stress response (ISR), in ASD remains poorly understood. Here, we demonstrate that the main arm of the ISR, eIF2α phosphorylation (p-eIF2α), is suppressed in excitatory, but not inhibitory, neurons in a mouse model of fragile X syndrome (FXS; Fmr1).
View Article and Find Full Text PDFActivation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (PNNs), in lamina I of the spinal cord dorsal horn.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers used single-cell RNA sequencing to discover that nerve injury creates a specific inflammatory microglia subtype in males, resulting in greater microglial proliferation compared to females.
- * The findings highlight the gene Apolipoprotein E (Apoe) as being significantly upregulated in chronic pain scenarios and link variations in the human APOE gene to chronic pain, revealing a common disease-related microglial subpopulation in both mice and humans.