Publications by authors named "Alba M Arbiol Enguita"
In this study, we employed stimulated Raman scattering (SRS) microscopy, augmented with sum frequency generation, to characterize complex solid-state mixtures, containing many solid-state forms of the same compound, for the first time. Five crystalline forms and one amorphous form of lactose were characterized and resolved, including two more recently defined anhydrous solid-state forms. Additionally, the complex solid-state character of several commercially available pharmaceutical tableting and inhalation grades of lactose was profiled.
View Article and Find Full Text PDFLiquid-liquid phase separation (LLPS) plays a pivotal role in processes ranging from cellular structure reorganization to the formation of crystalline structures in materials science. In the pharmaceutical field, it has been demonstrated to impact drug crystallization and delivery. To date, characterization of LLPS has been limited to nonspatially resolved or nonchemically resolved analyses.
View Article and Find Full Text PDFInsights into pharmaceutical co-crystallization using coherent Raman microscopy.
J Pharm Sci
January 2025
Article Synopsis
- This study focuses on the process of creating co-crystals of active pharmaceutical ingredients (APIs) and highlights the importance of understanding co-crystallization behaviors under different conditions.
- The researchers utilized two advanced imaging techniques, narrowband CARS and hyperspectral SRS, to observe co-crystallization in real-time, revealing key differences in component identification and overall co-crystal formation.
- The findings provide new insights into the co-crystallization process, including unexpected trace forms and the influence of ethanol content on co-crystal stability during milling.