Publications by authors named "Akke Ganse-Dumrath"
Apathy is a prevalent and persistent neuropsychiatric syndrome across many neurological disorders, significantly impacting both patients and caregivers. We systematically quantified discrepancies between self- and caregiver-reported apathy in 335 patients with a variety of diagnoses, such as frontotemporal dementia (behavioural variant and semantic dementia subtypes), Parkinson's disease, Parkinson's disease dementia, dementia with Lewy bodies, Alzheimer's disease dementia, mild cognitive impairment, small vessel cerebrovascular disease, subjective cognitive decline and autoimmune encephalitis. Using the Apathy Motivation Index (AMI) and its analogous caregiver version (AMI-CG), we found that caregiver-reported apathy consistently exceeded self-reported levels across all conditions.
View Article and Find Full Text PDFNon-affective psychotic disorders are marked by cognitive and sensory processing abnormalities, including in early visual processing and social cognition. Understanding the relationships between these deficits and their impact on daily-life functional outcomes may help to improve outcomes in affected individuals. This systematic review and meta-analysis aimed to summarise the existing evidence on the relationships between early visual processing, social cognition, and functional outcomes, and to assess the evidence regarding the mediating role of social cognition in the association between early visual processing and functional outcomes in individuals with schizophrenia spectrum disorders.
View Article and Find Full Text PDFArticle Synopsis
- The hippocampus plays a crucial role in decision-making, especially when evaluating uncertain values.
- Individuals with autoimmune limbic encephalitis, which affects the hippocampus, showed reduced sensitivity to changes in reward and effort when faced with uncertainty, despite being able to assess them without uncertainty.
- The findings suggest that the hippocampus is essential for making value-based decisions specifically in uncertain situations, and its damage correlates with worse performance in these scenarios.
Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease.
Alzheimers Dement (Amst)
April 2024
Introduction: A major limitation in Alzheimer's disease (AD) research is the lack of the ability to measure cognitive performance at scale-robustly, remotely, and frequently. Currently, there are no established online digital platforms validated against plasma biomarkers of AD.
Methods: We used a novel web-based platform that assessed different cognitive functions in AD patients ( = 46) and elderly controls ( = 53) who were also evaluated for plasma biomarkers (amyloid beta 42/40 ratio, phosphorylated tau ([p-tau]181, glial fibrillary acidic protein, neurofilament light chain).
Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study.
EClinicalMedicine
February 2024
Article Synopsis
- COVID-19 survivors may experience chronic cognitive symptoms as part of post-COVID-19 conditions (PCC), leading researchers to explore cognitive slowing as a potential marker for these conditions.
- In a study involving 270 PCC patients in the UK and Germany, cognitive tests revealed that patients exhibited significant slowing in response times compared to both recovered COVID patients without PCC and uninfected individuals.
- The observed cognitive deficits were consistent across different clinics and were correlated with sustained attention challenges, while factors like fatigue and anxiety did not explain the severity of cognitive slowing.