Publications by authors named "Ajay Premkumar"

Background: In cases of isolated, single-compartment osteoarthritis of the knee, both unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) can be effective treatment options. This study evaluated rates of technology-assisted utilization in UKA (TA-UKA) using a national claims database over a contemporary 13-year period to determine the trends in use of TA-UKA relative to TKA in the United States.

Methods: Patients undergoing primary UKA and TKA from 2009 to 2022 were identified using a large national claims database.

View Article and Find Full Text PDF

Background: Hip fractures represent devastating injuries with extensive morbidity and mortality. Despite guidelines recommending osteoporosis pharmacotherapy after hip fracture, treatment rates remain low. This study sought to determine the effect of osteoporosis pharmacotherapy on the secondary hip fracture rate in patients undergoing operative treatment for femoral neck fracture (FNFx).

View Article and Find Full Text PDF

The development of bacterial biofilm is central to the pathogenesis of periprosthetic joint infections following arthroplasty. Consequently, biofilm research in orthopedic surgery has expanded. This study assessed the quality of current orthopedic literature pertaining to the study of biofilm and identified the most commonly used study designs and techniques.

View Article and Find Full Text PDF

Purpose: Opioids prescribed to reduce pain and aid in recovery following anterior cruciate ligament reconstruction (ACLR) may pose a risk of future substance use disorder. The purpose of this study was to determine if pre-operative anxiety and depression differentiated opioid intake following ACLR. The contribution of sex, age, and graft type to post-operative opioid usage was also explored.

View Article and Find Full Text PDF

Background: Conversion total hip arthroplasty (THA) after prior hip surgery is generally associated with higher rates of complications when compared to primary THA. There is a paucity of evidence examining the influence of surgical approach on outcomes of conversion THA. This study compares complication rates between direct anterior approach (DAA) and posterior approach (PA) in patients with prior hip or acetabular fracture fixation undergoing conversion THA.

View Article and Find Full Text PDF

Background: The proportion of patients undergoing total knee arthroplasty (TKA) who are on chronic anticoagulation (CA) is increasing. As existing literature is limited, the purpose of this study was to compare complication rates after primary TKA among patients who were vs were not on CA.

Methods: This is a retrospective cohort study using the IBM MarketScan databases.

View Article and Find Full Text PDF

Background: Several studies have presented findings in favor of using extended oral antibiotic (EOA) prophylaxis to reduce periprosthetic joint infection (PJI) after primary total hip arthroplasty (THA) in patients at high risk for infection. To date, there is a paucity of evidence examining this topic from large retrospective databases. This study explored 90-day complication rates and 2-year PJI-free survivorship in a large cohort of patients receiving EOA prophylaxis after primary THA.

View Article and Find Full Text PDF

Introduction: Recent evidence has emerged supporting the use of extended oral antibiotic (EOA) prophylaxis after primary total knee replacement (TKA) to reduce periprosthetic joint infection (PJI) in high-risk patients. However, much of the evidence stems from single-institution series with limited sample sizes. This study aimed to explore the impact of EOA on complications and infection-free survivorship in a large cohort of patients after primary TKA.

View Article and Find Full Text PDF

Introduction: Tibial plateau fractures are common injuries that pose a significant risk of post-traumatic osteoarthritis (PTOA) despite surgical fixation. Though total knee arthroplasty (TKA) has been proven as a viable treatment option for PTOA, there is a higher risk of postoperative complications in patients with prior tibial plateau fracture (TPF). This systematic review aimed to evaluate surgical considerations and outcomes of TKA in patients with prior TPF fixation.

View Article and Find Full Text PDF

Background: The hip dysfunction and osteoarthritis outcome score for joint replacement (HOOS JR) has been widely used to assess patient hip function. The subjective hip value (SHV) has become increasingly recognized as an efficient single-question survey for assessing hip joint function. This study aimed to determine the psychometric properties of the SHV in evaluating hip function in patients undergoing total hip arthroplasty (THA) in correlation with the traditional HOOS JR.

View Article and Find Full Text PDF

Background: Most patients undergoing total knee arthroplasty (TKA) report moderate to severe pain in the acute postoperative period. Recent preliminary data have suggested that a short course of oral corticosteroid may improve early postoperative pain after various orthopedic operations, but the safety of this practice has not been rigorously evaluated in larger patient populations. The purpose of this study was to evaluate complication rates in patients receiving a methylprednisolone taper (MT) vs controls after primary TKA.

View Article and Find Full Text PDF

Background: A rise in total knee arthroplasty (TKA) volume has led to an increased incidence of aseptic revision TKA (rTKA), resulting in major associated health care costs. This study evaluated the economic impact and clinical factors associated with readmission following aseptic rTKA, aiming to identify key drivers of cost and risk factors for readmission.

Methods: This retrospective analysis used data from a large national database from January 1, 2009, to June 30, 2022.

View Article and Find Full Text PDF

Background: Glucagon-like peptide-1 (GLP-1) agonists have emerged as a powerful diabetic treatment adjunct; however, its effects on outcomes following total knee arthroplasty (TKA) are not well known. The purpose of this study was to compare the risk of complications after TKA in patients with type-2 diabetes who were on GLP-1 agonists with those who were not.

Methods: In total, 34,696 type 2 diabetes patients undergoing primary TKA between 2016 and 2021 were retrospectively reviewed utilizing a large national database.

View Article and Find Full Text PDF
Article Synopsis
  • Initial hinge designs for total knee arthroplasty had issues with loosening, but this study focuses on contemporary rotating-hinge implants.
  • A retrospective review of 54 surgeries from 2014 to 2018 showed promising outcomes, with a patient demographic mostly of older women dealing with severe knee instability.
  • Results indicated a 95% reoperation-free survival rate at 2 and 5 years, significant improvements in patient-reported quality of life, and no signs of aseptic loosening on follow-up imaging.
View Article and Find Full Text PDF

Background: Recent evidence suggests extended courses of oral antibiotics (EOA) after total hip arthroplasty and total knee arthroplasty (TKA) may reduce the risk of periprosthetic joint infection in high-risk patients. EOA rates after total hip arthroplasty have risen significantly. However, there is a lack of epidemiologic data on EOA prophylaxis following TKA.

View Article and Find Full Text PDF

Background: Glucagon-like peptide-1 (GLP-1) agonists have emerged as a powerful diabetic treatment adjunct; however, their effects on outcomes following total hip arthroplasty (THA) are not well known. This study aimed to compare the risk of complications in patients who had type 2 diabetes mellitus (DM) who were on GLP-1 agonists with those who were not on these medications.

Methods: In total, 14,065 patients who had type 2 DM undergoing primary THA between 2016 and 2021 were retrospectively reviewed using a national database.

View Article and Find Full Text PDF
Article Synopsis
  • Mechanically assisted crevice corrosion can complicate total hip arthroplasty (THA), potentially leading to adverse local tissue reactions (ALTR) due to metal ions released in the body.
  • A study examined 552 THA patients, focusing on the relationship between synovial fluid (SF) cobalt and chromium ion levels and the risk of developing ALTR, analyzing preoperative and intraoperative samples.
  • The findings showed no correlation between SF ion levels and ALTR; elevated serum cobalt levels were predictive of ALTR, indicating that SF measurements add no value over serum levels for diagnosing this condition.
View Article and Find Full Text PDF
Article Synopsis
  • A systematic review was conducted to examine how patient characteristics in randomized controlled trials (RCTs) for revision total joint arthroplasty (rTJA) compare with those in the general US patient population undergoing similar procedures.
  • The study analyzed 46 RCTs, finding that demographic factors such as age and BMI showed only small differences when compared to national patient cohorts from HCUP NIS and ACS-NSQIP.
  • The findings suggest that the rTJA RCT patient population closely resembles the broader US demographic, with minimal differences that are unlikely to affect clinical outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • The study assessed the reliability and validity of the Paprosky classification for acetabular bone loss, particularly looking at how accurate preoperative classifications and treatment selections are compared to intraoperative assessments.
  • Seventy-four patients were analyzed, and six raters of varying training levels independently evaluated Paprosky classifications using preoperative radiographs; their agreement was measured using Cohen's Kappa.
  • Results showed that inter-rater reliability was poor to moderate across training levels, with only fair agreement between preoperative and intraoperative classifications and treatment selections.
View Article and Find Full Text PDF
Article Synopsis
  • Sub-Saharan Africa faces a substantial burden of musculoskeletal trauma, with a lack of reports on the adequacy of surgical care and factors that contribute to inadequacies.
  • Data was collected from patients treated at an orthopaedic trauma center over 6 weeks to assess whether surgical treatments restored necessary alignment and rotation; exclusions were made for specific cases that didn't fit the study criteria.
  • Out of 112 analyzed cases, surgery was deemed inadequate in 42.9% due to factors like the unavailability of proper implants and intraoperative imaging, highlighting significant systemic shortcomings in providing effective fracture care.
View Article and Find Full Text PDF

The direct anterior approach (DAA) has been increasing in popularity for primary total hip arthroplasty (THA). Despite previously documented anatomic limitations to its direct distal extension, alternative exposure methods have been described to safely access the femoral diaphysis and facilitate increasingly complex primary and revision THA scenarios. The DAA has several purported advantages compared to alternative approaches (eg, posterior and lateral-based), including its muscle-sparing nature, use of an internervous plane, and preservation of posterior stabilizing structures.

View Article and Find Full Text PDF

Background: Total hip arthroplasty (THA) is an effective surgical treatment for severe osteoarthritis of the hip. While THA is considered a reliable and safe procedure, outcome data on patients who have Ehlers-Danlos syndrome (EDS) is limited. The purpose of this study was to compare rates of postoperative complications after primary THA in patients who have EDS against matched controls.

View Article and Find Full Text PDF

Background: Artificial intelligence (AI) in medicine has primarily focused on diagnosing and treating diseases and assisting in the development of academic scholarly work. This study aimed to evaluate a new use of AI in orthopaedics: content generation for professional medical education. Quality, accuracy, and time were compared between content created by ChatGPT and orthopaedic surgery clinical fellows.

View Article and Find Full Text PDF

Tanzania is disproportionately burdened by musculoskeletal injuries as it faces unique challenges when dealing with trauma care. This scoping review aims to summarize and assess the current state of orthopaedic and trauma research in Tanzania. By identifying key themes, trends, and gaps in the literature, this review seeks to guide future research initiatives catered specifically to the needs of Tanzania's healthcare system.

View Article and Find Full Text PDF
Article Synopsis
  • Total knee arthroplasty (TKA) is an effective surgery for patients with severe knee osteoarthritis, but there's limited information on outcomes for those with Ehlers-Danlos syndrome (EDS).
  • This study analyzed a large database from 2009 to 2020, comparing complication rates post-TKA in EDS patients to matched controls based on age, sex, and other health issues.
  • Results indicated that EDS patients had a significantly higher rate of wound complications within 90 days post-surgery, though other complications did not differ significantly between the two groups.
View Article and Find Full Text PDF